• Product name

    Anti-AMACR antibody - BSA and Azide free
    See all AMACR primary antibodies
  • Description

    Rabbit polyclonal to AMACR - BSA and Azide free
  • Host species

  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide. The exact sequence is proprietary.
    Database link: Q9UHK6

  • Positive control

    • Human lung carcinoma and prostate carcinoma tissues
  • General notes

     This product was previously labelled as AMACR, AMCR



Our Abpromise guarantee covers the use of ab212378 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.


  • Function

    Racemization of 2-methyl-branched fatty acid CoA esters. Responsible for the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers.
  • Pathway

    Lipid metabolism; bile acid biosynthesis.
    Lipid metabolism; fatty acid metabolism.
  • Involvement in disease

    Defects in AMACR are the cause of alpha-methylacyl-CoA racemase deficiency (AMACRD) [MIM:614307]. AMACRD results in elevated plasma concentrations of pristanic acid C27-bile-acid intermediates. It can be associated with polyneuropathy, retinitis pigmentosa, epilepsy.
    Defects in AMACR are the cause of congenital bile acid synthesis defect type 4 (CBAS4) [MIM:214950]; also known as cholestasis, intrahepatic, with defective conversion of trihydroxycoprostanic acid to cholic acid or trihydroxycoprostanic acid in bile. Clinical features include neonatal jaundice, intrahepatic cholestasis, bile duct deficiency and absence of cholic acid from bile.
  • Sequence similarities

    Belongs to the CaiB/BaiF CoA-transferase family.
  • Cellular localization

    Peroxisome. Mitochondrion.
  • Information by UniProt
  • Database links

  • Alternative names

    • 2 arylpropionyl CoA epimerase antibody
    • 2 methylacyl CoA racemase antibody
    • 2-methylacyl-CoA racemase antibody
    • Alpha methylacyl CoA racemase antibody
    • Alpha methylacyl Coenzyme A racemase antibody
    • Alpha methylacyl-CoA racemase deficiency, included antibody
    • Alpha-methylacyl-CoA racemase antibody
    • Amacr antibody
    • AMACR deficiency, included antibody
    • AMACR_HUMAN antibody
    • CBAS4 antibody
    • Da1-8 antibody
    • EC antibody
    • Macr1 antibody
    • Methylacyl CoA racemase alpha antibody
    • RACE antibody
    • RM antibody
    see all


  • Immunohistochemical analysis of formalin fixed paraffin-embedded human prostate carcinoma tissue sections labeling AMACR with ab212378 at a 1/50 dilution.

  • Immunohistochemical analysis of paraffin embedded, formalin fixed human lung carcinoma tissue labeling AMACR with ab212378 at 1/50 dilution.


ab212378 has not yet been referenced specifically in any publications.

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