Overview

  • Product name

    Anti-AMACR antibody [RM349] - N-terminal
    See all AMACR primary antibodies
  • Description

    Rabbit monoclonal [RM349] to AMACR - N-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human AMACR (N terminal).
    Database link: Q9UHK6

  • Positive control

    • WB: LNCaP cell lysate. IHC-P: Human kidney tissue.
  • General notes

     This product was previously labelled as AMACR, AMCR

     

Properties

Applications

Our Abpromise guarantee covers the use of ab238312 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/2000. Predicted molecular weight: 42 kDa.
IHC-P 1/500 - 1/1000.

Target

  • Function

    Racemization of 2-methyl-branched fatty acid CoA esters. Responsible for the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers.
  • Pathway

    Lipid metabolism; bile acid biosynthesis.
    Lipid metabolism; fatty acid metabolism.
  • Involvement in disease

    Defects in AMACR are the cause of alpha-methylacyl-CoA racemase deficiency (AMACRD) [MIM:614307]. AMACRD results in elevated plasma concentrations of pristanic acid C27-bile-acid intermediates. It can be associated with polyneuropathy, retinitis pigmentosa, epilepsy.
    Defects in AMACR are the cause of congenital bile acid synthesis defect type 4 (CBAS4) [MIM:214950]; also known as cholestasis, intrahepatic, with defective conversion of trihydroxycoprostanic acid to cholic acid or trihydroxycoprostanic acid in bile. Clinical features include neonatal jaundice, intrahepatic cholestasis, bile duct deficiency and absence of cholic acid from bile.
  • Sequence similarities

    Belongs to the CaiB/BaiF CoA-transferase family.
  • Cellular localization

    Peroxisome. Mitochondrion.
  • Information by UniProt
  • Database links

  • Alternative names

    • 2 arylpropionyl CoA epimerase antibody
    • 2 methylacyl CoA racemase antibody
    • 2-methylacyl-CoA racemase antibody
    • Alpha methylacyl CoA racemase antibody
    • Alpha methylacyl Coenzyme A racemase antibody
    • Alpha methylacyl-CoA racemase deficiency, included antibody
    • Alpha-methylacyl-CoA racemase antibody
    • Amacr antibody
    • AMACR deficiency, included antibody
    • AMACR_HUMAN antibody
    • CBAS4 antibody
    • Da1-8 antibody
    • EC 5.1.99.4 antibody
    • Macr1 antibody
    • Methylacyl CoA racemase alpha antibody
    • RACE antibody
    • RM antibody
    see all

Images

  • Anti-AMACR antibody [RM349] - N-terminal (ab238312) at 1/1000 dilution + LNCaP (Human prostate cancer cell line) cell lysate

    Predicted band size: 42 kDa

  • Formalin-fixed, paraffin-embedded human kidney tissue stained for AMACR using ab238312 at 1/1000 dilution in immunohistochemical analysis.

References

ab238312 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab238312.
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