Overview

  • Product name

    Amantadine hydrochloride, Dopaminergic agent
  • Description

    Dopaminergic agent. Antiviral.
  • Biological description

    Antiviral agent. Dopaminergic agent. Binds to M2 proton-selective ion channel of influenza. Uncompetitive NMDA receptor antagonist. Inhibits dopamine reuptake and induces D2 and D3 upregulation. Shows antiviral, antiparkinsonian and neuroprotective effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    665-66-7
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Jing X  et al. Functional studies indicate amantadine binds to the pore of the influenza A virus M2 proton-selective ion channel. Proc Natl Acad Sci U S A 105:10967-72 (2008). Read more (PubMed: 18669647) »
  • Rogóz Z  et al. Effect of combined treatment with imipramine and amantadine on the central dopamine D2 and D3 receptors in rats. J Physiol Pharmacol 54:257-70 (2003). Read more (PubMed: 12832726) »
  • Kornhuber J  et al. Amantadine and memantine are NMDA receptor antagonists with neuroprotective properties. J Neural Transm Suppl 43:91-104 (1994). Read more (PubMed: 7884411) »
  • Kornhuber J  et al. Effects of the 1-amino-adamantanes at the MK-801-binding site of the NMDA-receptor-gated ion channel: a human postmortem brain study. Eur J Pharmacol 206:297-300 (1991). Read more (PubMed: 1717296) »

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