Product nameAmbenonium chloride, acetylcholinesterase (AChE) inhibitor
DescriptionPotent, selective, reversible acetylcholinesterase (AChE) inhibitor
- Ambestigmin chloride
- N,N'-[(1,2-Dioxo-1,2-ethanediyl)bis(imino-2,1-ethanediyl)]bis(2-chloro-N,N-diethylbenzenemethaminium) dichloride
Extremely potent, selective and rapidly reversible acetylcholinesterase (AChE) inhibitor (IC50 values are 0.0007 and 7 μM at AChE and BChE respectively). Used in the management of myasthenia gravis.
Chemical nameN,N'-[(1,2-Dioxo-1,2-ethanediyl)bis(imino-2,1-ethanediyl)]bis[2-chloro-N,N-diethylbenzenemethanaminium] dichloride
Storage instructionsStore at +4°C. The product can be stored for up to 12 months.
Solubility overviewSoluble in water
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
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This product has been referenced in:
- Komloova M et al. Preparation, in vitro screening and molecular modelling of symmetrical bis-quinolinium cholinesterase inhibitors--implications for early myasthenia gravis treatment. Bioorg Med Chem Lett 21:2505-9 (2011). Read more (PubMed: 21397501) »
- Bolognesi ML et al. Design, synthesis and biological evaluation of ambenonium derivatives as AChE inhibitors. Farmaco 58:917-28 (2003). Read more (PubMed: 13679187) »
- Hodge AS et al. Ambenonium is a rapidly reversible noncovalent inhibitor of acetylcholinesterase, with one of the highest known affinities. Mol Pharmacol 41:937-42 (1992). Read more (PubMed: 1588924) »
- Papp M Fine structural analysis of the localization of acetylcholinesterase accessible to intraventricular ambenonium chloride in rabbit brain. Neuroscience 4:825-36 (1979). Read more (PubMed: 481753) »