Overview

  • Product name

    Ambroxol hydrochloride, Nachannel blocker
  • Description

    Antioxidant, anti-inflammatory agent. Na+ channel blocker and mucolytic agent.
  • Biological description

    Antioxidant, anti-inflammatory agent. Na+ channel blocker and mucolytic agent. Stimulates surfactant secretion and produces expectorant effects by decreasing mucus adhesion to the bronchial lining. Inhibits histamine secretion from mast cells.
  • Purity

    > 99%
  • CAS Number

    23828-92-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4-[(2-Amino-3,5-dibromophenyl)methylamino]cyclohexan-1-ol hydrochloride
  • Molecular weight

    414.60
  • Molecular formula

    C13H18Br2N2O.HCl
  • PubChem identifier

    108013
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 10 mM, in DMSO to 100 mM and in ethanol to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1CC(CCC1NCC2=CC(=CC(=C2N)Br)Br)O.Cl
  • Source

    Synthetic

  • Research areas

Images

  • Ambroxol hydrochloride inhibits NaV1.7 channels expressed in HEK293 cells.

    A: Time course of current reversible inhibition by 100 µM Ambroxol hydrochloride (ab141778). Currents were elicited by a voltage ramp from a holding potential of -100 mV to 60 mV (30 ms) delivered every 10 seconds.

    B: Example traces of current response to voltage ramp stimulation before and during 100 µM Ambroxol hydrochloride application.

References

This product has been referenced in:

  • Zhao F  et al. [Optimization of a floating osmotic pump system of ambroxol hydrochloride using central composite design-response surface methodology and its pharmacokinetics in Beagle dogs]. Yao Xue Xue Bao 46:1507-14 (2011). Read more (PubMed: 22375427) »
  • Seifart C  et al. Cell-specific modulation of surfactant proteins by ambroxol treatment. Toxicol Appl Pharmacol 203:27-35 (2005). Read more (PubMed: 15694461) »
  • Kubo W  et al. Oral sustained delivery of ambroxol from in situ-gelling pectin formulations. Int J Pharm 271:233-40 (2004). Read more (PubMed: 15129990) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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