Overview

  • Product name

  • Description

    Rabbit polyclonal to AMD1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Chicken, Cow, Xenopus laevis
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 44-226 of Human AMD1 (P17707).

  • Positive control

    • 293T, A431, Jurkat and Raji whole cell lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab127576 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 38 kDa.

Target

  • Pathway

    Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.
  • Sequence similarities

    Belongs to the eukaryotic AdoMetDC family.
  • Post-translational
    modifications

    Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.
  • Information by UniProt
  • Database links

  • Alternative names

    • Adenosylmethionine decarboxylase 1 antibody
    • AdoMetDC antibody
    • AMD1 antibody
    • DCAM_HUMAN antibody
    • EC 4.1.1.50 antibody
    • FLJ26964 antibody
    • S adenosylmethionine decarboxylase 1 antibody
    • S adenosylmethionine decarboxylase proenzyme antibody
    • S-adenosylmethionine decarboxylase beta chain antibody
    • SAMDC antibody
    see all

Images

  • Anti-AMD1 antibody (ab127576) at 1/1000 dilution + A431 whole cell lysate at 30 µg

    Predicted band size: 38 kDa



    10% SDS PAGE

References

ab127576 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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