Anti-gp78 antibody (ab76841)
Key features and details
- Rabbit polyclonal to gp78
- Suitable for: IHC-Fr, IHC-P, WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-gp78 antibody
See all gp78 primary antibodies -
Description
Rabbit polyclonal to gp78 -
Host species
Rabbit -
Specificity
ab76841 reacts specifically with the 73 kda (isoform 2) protein. -
Tested applications
Suitable for: IHC-Fr, IHC-P, WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse -
Immunogen
Synthetic peptide corresponding to Human gp78 (C terminal).
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
Constituent: Whole serum -
Concentration information loading...
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Purity
Whole antiserum -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab76841 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-Fr |
Use at an assay dependent concentration.
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IHC-P |
Use at an assay dependent concentration.
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WB | (1) |
Use at an assay dependent concentration.
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Notes |
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IHC-Fr
Use at an assay dependent concentration. |
IHC-P
Use at an assay dependent concentration. |
WB
Use at an assay dependent concentration. |
Target
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Function
E3 ubiquitin-protein ligase which can target both itself and other proteins including CD3D and APOB for proteasomal degradation. Mediates polyubiquitination of CYP3A4. Specific receptor for the autocrine motility factor. Mediates tumor invasion and metastasis. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulun that are retrotranslocated in the cytosol. Promotes ubiquitination of misfolded proteins such as mutant CFTR; proposed to mediate sequential ubiquitination by recognizing already ubiquitin-conjugated substrates and to cooperate with E3 ubiquitin-protein ligase RNF5. -
Pathway
Protein modification; protein ubiquitination. -
Sequence similarities
Contains 1 CUE domain.
Contains 1 RING-type zinc finger. -
Cellular localization
Endoplasmic reticulum membrane. - Information by UniProt
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Database links
- Entrez Gene: 267 Human
- Entrez Gene: 23802 Mouse
- Omim: 603243 Human
- SwissProt: Q9UKV5 Human
- SwissProt: Q9R049 Mouse
- Unigene: 295137 Human
- Unigene: 34641 Mouse
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Alternative names
- AMF receptor antibody
- AMF receptor isoform 1 antibody
- AMF receptor isoform 2 antibody
see all
Protocols
Datasheets and documents
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Datasheet download
References (2)
ab76841 has been referenced in 2 publications.
- Li Y et al. Autocrine motility factor promotes endometrial cancer progression by targeting GPER-1. Cell Commun Signal 17:22 (2019). PubMed: 30836961
- Jung HS et al. Monoclonal antibodies against autocrine motility factor suppress gastric cancer. Oncol Lett 13:4925-4932 (2017). PubMed: 28599497