Overview

  • Product name

  • Description

    Goat polyclonal to AMHR2
  • Host species

    Goat
  • Specificity

    ab205398 is expected to recognize all reported isoforms (NP_065434.1; NP_001158162.1; NP_001158163.1).
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide corresponding to Human AMHR2 aa 88-99 (internal sequence). (NP_065434.1).
    Sequence:

    ESLHCDPSPRAH


    Database link: Q16671

  • Positive control

    • MDA-MB-231 cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab205398 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 60, 65 kDa (predicted molecular weight: 63 kDa).

Target

  • Function

    On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.
  • Involvement in disease

    Defects in AMHR2 are the cause of persistent Muellerian duct syndrome type 2 (PMDS2) [MIM:261550]. PMDS2 is a form of male pseudohermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males.
  • Sequence similarities

    Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
    Contains 1 protein kinase domain.
  • Cellular localization

    Membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • AMH type II receptor antibody
    • AMHR antibody
    • AMHR2 antibody
    • AMHR2_HUMAN antibody
    • Anti Mullerian hormone receptor, type II antibody
    • Anti-Muellerian hormone type II receptor antibody
    • Anti-Muellerian hormone type-2 receptor antibody
    • MGC141312 antibody
    • MIS type II receptor antibody
    • MISR2 antibody
    • MISRII antibody
    • MRII antibody
    • Muellerian hormone type 2 receptor antibody
    • Muellerian hormone type II receptor antibody
    • Muellerian inhibiting substance type II receptor antibody
    • Mullerian hormone receptor type II antibody
    • Mullerian inhibiting substance type II receptor antibody
    see all

Images

  • Anti-AMHR2 antibody (ab205398) at 1 µg/ml + MDA-MB-231 cell lysate (in RIPA buffer) at 35 µg

    Developed using the ECL technique.

    Predicted band size: 63 kDa



    Approx 60+65kDa bands observed. The observed molecular weights can be explained by glycosylation of the mature isoforms.

    Primary incubation was 1 hour.

References

ab205398 has not yet been referenced specifically in any publications.

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