Overview

  • Product name

    AMI 1, protein arginine methyltransferase inhibitor
  • Description

    Potent, selective and reversible protein arginine methyltransferase inhibitor
  • Biological description

    Potent, selective and reversible protein arginine methyltransferase inhibitor (IC50 = 1.63 μM). ROS° scavenger with antioxidant effects (IC50 = 8.3 μM). Inhibits arginine in vitro without competing for the AdoMet binding site. Modulates nuclear receptor-regulated transcription in vivo. Cell-permeable.
  • Purity

    > 97%
  • CAS Number

    20324-87-2
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Sun Q  et al. Upregulated protein arginine methyltransferase 1 by IL-4 increases eotaxin-1 expression in airway epithelial cells and participates in antigen-induced pulmonary inflammation in rats. J Immunol 188:3506-12 (2012). Read more (PubMed: 22387551) »
  • Chen F & Fulton DJ An inhibitor of protein arginine methyltransferases, 7,7'-carbonylbis(azanediyl)bis(4-hydroxynaphthalene-2-sulfonic acid (AMI-1), is a potent scavenger of NADPH-oxidase-derived superoxide. Mol Pharmacol 77:280-7 (2010). Read more (PubMed: 19903831) »
  • Cheng D  et al. Small molecule regulators of protein arginine methyltransferases. J Biol Chem 279:23892-9 (2004). Read more (PubMed: 15056663) »

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