Overview

  • Product name

    AMI-5 (Eosin Y), PRMT inhibitor
  • Description

    Non-selective PRMT inhibitor. Stain for cytoplasm.
  • Alternative names

    • Eosin Y
  • Biological description

    Non-selective PRMT inhibitor (IC50 values are 0.8 and 1.4 μM for Hmt1p and PRMT1 respectively). Stain for cytoplasm. Inhibits DOT1 and SET7. Decreases methylation of H3 histones at lysine 4.
  • Purity

    > 90%
  • CAS Number

    17372-87-1
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Mortazavi M  et al. Protective Effects of Antioxidants on Sperm Parameters and Seminiferous Tubules Epithelium in High Fat-fed Rats. J Reprod Infertil 15:22-8 (2014). Read more (PubMed: 24696792) »
  • Okabe J  et al. Endothelial transcriptome in response to pharmacological methyltransferase inhibition. ChemMedChem 9:1755-62 (2014). Read more (PubMed: 24850797) »
  • Mai A  et al. epigenetic multiple ligands: mixed histone/protein methyltransferase, acetyltransferase, and class III deacetylase (sirtuin) inhibitors. J Med Chem 51:2279-90 (2008). Read more (PubMed: 18348515) »

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