Overview

  • Product name

    Amidepsine A, DGAT inhibitor
  • Description

    DGAT inhibitor
  • Biological description

    DGAT inhibitor (IC50 values are 10.2 and 15.5 μM for rat liver microsomes and Raji cells respectively). Amidepsine D (ab144180) analog. May show antiobesogenic and antidiabetic effects in vivo.
  • Purity

    > 95%
  • CAS Number

    169181-28-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-[[4-[4-(2,4-Dimethoxy-6-methylbenzoyl)oxy-2-hydroxy-6-methylbenzoyl]oxy-2-hydroxy-6-methylbenzoyl]amino]propanoic acid
  • Molecular weight

    567.54
  • Molecular formula

    C29H29NO11
  • PubChem identifier

    10099481
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=CC(=CC(=C1C(=O)NC(C)C(=O)O)O)OC(=O)C2=C(C=C(C=C2C)OC(=O)C3=C(C=C(C=C3C)OC)OC)O
  • Source

    Humcola sp.

  • Research areas

References

This product has been referenced in:

  • Tomoda H  et al. Amidepsine E, an inhibitor of diacylglycerol acyltransferase produced by Humicola sp. FO-5969. J Antibiot (Tokyo) 49:929-31 (1996). Read more (PubMed: 8931727) »
  • Tomoda H  et al. Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942. I. Production, isolation and biological properties. J Antibiot (Tokyo) 48:937-41 (1995). Read more (PubMed: 7592058) »
  • Tomoda H  et al. Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942. II. Structure elucidation of amidepsines A, B and C. J Antibiot (Tokyo) 48:942-7 (1995). Read more (PubMed: 7592059) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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