Overview

  • Product name

    Amidepsine D, DGAT inhibitor
  • Description

    DGAT inhibitor
  • Biological description

    DGAT inhibitor (IC50 values are 17.5 and 2.8 μM for rat liver microsomes and Raji cells respectively). May show hepatoprotective and antidiabetic effects in vivo.
  • Purity

    > 95%
  • CAS Number

    79786-34-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4-[4-(2,4-Dimethoxy-6-methylbenzoyl)oxy-2-hydroxy-6-methylbenzoyl]oxy-2-hydroxy-6-methylbenzoic acid
  • Molecular weight

    496.46
  • Molecular formula

    C26H24O10
  • PubChem identifier

    10391109
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=CC(=CC(=C1C(=O)O)O)OC(=O)C2=C(C=C(C=C2C)OC(=O)C3=C(C=C(C=C3C)OC)OC)O
  • Source

    Humcola sp.

  • Research areas

References

This product has been referenced in:

  • Arai M  et al. New monordens produced by amidepsine-producing fungus Humicola sp. FO-2942. J Antibiot (Tokyo) 56:526-32 (2003). Read more (PubMed: 12931861) »
  • Yamamoto K  et al. Structure elucidation of new monordens produced by Humicola sp. FO-2942. J Antibiot (Tokyo) 56:533-8 (2003). Read more (PubMed: 12931862) »
  • Tomoda H  et al. Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942. II. Structure elucidation of amidepsines A, B and C. J Antibiot (Tokyo) 48:942-7 (1995). Read more (PubMed: 7592059) »

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