Aminopurvalanol A, cyclin-dependent kinase inhibitor (ab145052)

Overview

  • Product name

    Aminopurvalanol A, cyclin-dependent kinase inhibitor
  • Description

    Potent, cell-permeable cyclin-dependent kinase inhibitor
  • Biological description

    Potent, cell-permeable cyclin-dependent kinase inhibitor (IC50 values are 33 (cdk1/cyclin B), 33 (cdk2/cyclin A), 28 (cdk2/cyclin E) and 20 nM (cdk5/p35)). Inhibits ERK1 (IC50 = 12.0 μM) and ERK2 (IC50 = 3.1 μM). Induces cell cycle arrest at G2/M phase (IC50 = 1.25 μM). Shows apoptotic effects.
  • Purity

    > 99%
  • CAS Number

    220792-57-4
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Dobrikov MI  et al. Mitotic phosphorylation of eukaryotic initiation factor 4G1 (eIF4G1) at Ser1232 by Cdk1:cyclin B inhibits eIF4A helicase complex binding with RNA. Mol Cell Biol 34:439-51 (2014). Read more (PubMed: 24248602) »
  • Teo R  et al. An evolutionary conserved role of Wnt signaling in stem cell fate decision. Dev Biol 289:91-9 (2006). Read more (PubMed: 16309665) »
  • Donald RG  et al. Characterization of two T. gondii CK1 isoforms. Mol Biochem Parasitol 141:15-27 (2005). Read more (PubMed: 15811523) »

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