Amiodarone hydrochloride, Broad-spectrum ion channel blocker (ab141444)

Overview

  • Product name
    Amiodarone hydrochloride, Broad-spectrum ion channel blocker
  • Description
    Broad-spectrum ion channel blocker. Antiarrhythmic agent.
  • Biological description
    Broad-spectrum ion channel blocker. Class III antiarrhythmic agent. Blocks late INa, ICa, IKr and IKs and increases QT. Shows beta blocker-like effects on the SA and AV nodes in vivo. Orally active.
  • Purity
    > 98%

Properties

References

This product has been referenced in:
  • Brocks DR  et al. Effect of rat serum lipoproteins on mRNA levels and amiodarone metabolism by cultured primary rat hepatocytes. J Pharm Sci 102:262-70 (2013). Read more (PubMed: 23132435) »
  • Takahama H  et al. Liposomal amiodarone augments anti-arrhythmic effects and reduces hemodynamic adverse effects in an ischemia/reperfusion rat model. Cardiovasc Drugs Ther 27:125-32 (2013). Read more (PubMed: 23344929) »
  • Furutani K  et al. A mechanism underlying compound-induced voltage shift in the current activation of hERG by antiarrhythmic agents. Biochem Biophys Res Commun 415:141-6 (2011). Read more (PubMed: 22020101) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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