Overview

  • Product name

    Amisulpride, D2/D3 receptor antagonist
  • Description

    Potent, highly selective D2/D3 receptor antagonist
  • Biological description

    Potent, highly selective D2/D3 receptor antagonist (Ki values are 2.8 and 3.2 nM for D2 and D3 receptors respectively). Shows atypical antipsychotic effects in vivo. Orally active. Shows limbic selectivity.
  • Purity

    > 98%
  • CAS Number

    71675-85-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4-Amino-N-[(1-ethylpyrrolidin-2-yl)methyl]-5-ethylsulfonyl-2-methoxybenzamide
  • Molecular weight

    369.48
  • Molecular formula

    C17H27N3O4S
  • PubChem identifier

    2159
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 50 mM and ethanol to 100 mM (with warming)
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCN1CCCC1CNC(=O)C2=CC(=C(C=C2OC)N)S(=O)(=O)CC
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Möller HJ Amisulpride: limbic specificity and the mechanism of antipsychotic atypicality. Prog Neuropsychopharmacol Biol Psychiatry 27:1101-11 (2003). Read more (PubMed: 14642970) »
  • Perrault G  et al. Psychopharmacological profile of amisulpride: an antipsychotic drug with presynaptic D2/D3 dopamine receptor antagonist activity and limbic selectivity. J Pharmacol Exp Ther 280:73-82 (1997). Read more (PubMed: 8996184) »
  • Schoemaker H  et al. Neurochemical characteristics of amisulpride, an atypical dopamine D2/D3 receptor antagonist with both presynaptic and limbic selectivity. J Pharmacol Exp Ther 280:83-97 (1997). Read more (PubMed: 8996185) »

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