Amitriptyline hydrochloride, Serotonin and noradrenalin uptake inhibitor (ab141902)

Overview

  • Product name

    Amitriptyline hydrochloride, Serotonin and noradrenalin uptake inhibitor
  • Description

    Serotonin and noradrenalin uptake inhibitor
  • Biological description

    Serotonin and noradrenalin uptake inhibitor. Tricyclic antidepressant (TCA). Shows antidepressant and antinociceptive activity. Active in vivo.
  • Purity

    > 98%
  • CAS Number

    549-18-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-(5,6-Dihydrodibenzo[2,1-b:2',1'-f][7]annulen-11-ylidene)-N,N-dimethylpropan-1-amine hydrochloride
  • Molecular weight

    313.86
  • Molecular formula

    C20H23N.HCl
  • PubChem identifier

    11065
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble to 100 mM in water and to 100 mM in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CN(C)CCC=C1C2=CC=CC=C2CCC3=CC=CC=C31.Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • de Almeida Prado PS  et al. Amitriptyline aggravates the fibrosis process in a rat model of infravesical obstruction. Int J Exp Pathol 93:218-24 (2012). Read more (PubMed: 22563623) »
  • Parra A  et al. The effect of amitriptyline on inhibitory avoidance in mice is dose-dependent. Psicothema 21:528-30 (2009). Read more (PubMed: 19861093) »
  • Chowdary PS & Rao MS Cytogenetic effects of amitriptyline hydrochloride in somatic and germ cells of mice. Toxicol Lett 39:199-204 (1987). Read more (PubMed: 3686550) »

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