Amlodipine besylate, L-type calcium channel blocker (ab141777)

Overview

  • Product name

    Amlodipine besylate, L-type calcium channel blocker
  • Description

    Potent L-type calcium channel blocker
  • Biological description

    Potent L-type calcium channel blocker. Inhibits Ca2+induced contractions (IC50 = 2 nM). Shows antiproliferative effects. Shows antihypertensive effects in vivo. Orally active.
  • Purity

    > 99%
  • CAS Number

    111470-99-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-O-Ethyl 5-O-methyl-2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate benzenesulfonic acid
  • Molecular weight

    567.10
  • Molecular formula

    C20H25ClN2O5.C6H6O3S
  • PubChem identifier

    60496
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 10 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN.C1=CC=C(C=C1)S(=O)(=O)O
  • Source

    Synthetic

  • Research areas

Images

  • Amlodipine besylate blocks L-type Ca2+ currents in Xenopusoocytes.

    A. Time course of L-type channel (CaV1.2+a2d1+ß1a) activity before and during applications of 100 µM Amlodipine besylate (ab141777; green) and upon wash. Holding potential was -100 mV and currents were elicited every 10 seconds by 100 ms steps to 0 mV.

    B. Example current traces before (black) and during application of 100 µM Amlodipine besylate (taken from the experiment described in A).

References

This product has been referenced in:

  • Yoshida J  et al. Antiproliferative effect of Ca2+ channel blockers on human epidermoid carcinoma A431 cells. Eur J Pharmacol 472:23-31 (2003). Read more (PubMed: 12860469) »
  • Burges RA  et al. Calcium channel blocking properties of amlodipine in vascular smooth muscle and cardiac muscle in vitro: evidence for voltage modulation of vascular dihydropyridine receptors. J Cardiovasc Pharmacol 9:110-9 (1987). Read more (PubMed: 2434785) »
  • Henik RA  et al. Treatment of systemic hypertension in cats with amlodipine besylate. J Am Anim Hosp Assoc 33:226-34 (0). Read more (PubMed: 9138233) »

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