Overview

  • Product name
    Amlodipine, L-type calcium channel blocker
  • Description
    Potent, long-acting L-type calcium channel blocker
  • Biological description
    Potent, long-acting L-type calcium channel blocker (IC50=1.9 nM). Also stimulates nitric oxide synthase (NOS), lowers blood pressure and has antioxidant properties.
  • Purity
    > 98%

Properties

  • Chemical name
    3-O-Ethyl 5-O-methyl2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
  • Molecular weight
    408.88
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C20H25ClN2O5
  • CAS Number
    88150-42-9
  • PubChem identifier
    2162
  • Storage instructions
    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO to 50 mM and in ethanol to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • Chang H  et al. Simultaneous determination of amlodipine and bisoprolol in rat plasma by a liquid chromatography/tandem mass spectrometry method and its application in pharmacokinetic study. J Pharm Biomed Anal 71:104-10 (2012). Read more (PubMed: 22947502) »
  • Suzuki S  et al. Comparative effects of amlodipine and benazepril on left atrial pressure in dogs with experimentally-induced mitral valve regurgitation. BMC Vet Res 8:166 (2012). Read more (PubMed: 22989022) »
  • Khan NA  et al. Protective effects of amlodipine on mitochondrial injury in ischemic reperfused rat heart. J Environ Biol 33:591-5 (2012). Read more (PubMed: 23029908) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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