Overview

  • Product name
    AMN082 dihydrochloride, mGlu7 agonist
  • Description
    mGlu7 agonist
  • Biological description
    Potent, selective, orally active and brain penetrant mGlu7 receptor agonist. Potently inhibits cAMP accumulation and stimulates GTP binding (EC50 = 64-290 nM) in mGluR7 transfected cells. Selective over mGlu1, 2, 3, 4,5, 6, and 8, ionotropic receptors (up to 10 μM). Elevates plasma stress hormones in vivo. Induces mGlu7 receptor internalisation in dissociated hippocampal neurones.
  • Purity
    > 99%
  • CAS Number
    97075-46-2
  • Chemical structure
    Chemical Structure

Properties

Protocols

References

This product has been referenced in:
  • Pelkey KA  et al. mGluR7 undergoes rapid internalization in response to activation by the allosteric agonist AMN082. Neuropharmacology 52:108-17 (2007). Read more (PubMed: 16914173) »
  • Suzuki G  et al. In vitro pharmacological characterization of novel isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists. J Pharmacol Exp Ther 323:147-56 (2007). Read more (PubMed: 17609420) »
  • Mitsukawa K  et al. A selective metabotropic glutamate receptor 7 agonist: activation of receptor signaling via an allosteric site modulates stress parameters in vivo. Proc Natl Acad Sci U S A 102:18712-7 (2005). Read more (PubMed: 16339898) »
See all 11 Publications for this product

Customer reviews and Q&As

1-2 of 2 Abreviews or Q&A

Answer

Thank you for your enquiry regarding ab120011.

We weigh to a tolerance of +5% for the 50mg pack sizes so there is always at least 50mg in but there may be up to 52.5mg. On average it is likely to be somewhere in between – estimated to be 51.5 mg in each vial.

This shouldn’t affect the solubilisation as we round the solubility data to whole numbers rather than quote a saturated solution concentration.

If you need any further assistance in the future, please do not hesitate to contact me.

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Answer

Thank you for your reply. I apologize about this mistake.

ab120011 is AMN082 dihydrochloride. The country of manufacture is Great Britain.

I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

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