Overview

  • Product name

    Amonafide, topoisomerase II inhibitor
  • Description

    Selective topoisomerase II inhibitor
  • Biological description

    Selective topoisomerase II inhibitor. Induces DNA single-strand breaks, double-strand breaks, and DNA-protein cross-links. Shows antiproliferative effects (IC50 = 3-7 μM). Shows anticancer effects in vivo. Orally active.
  • Purity

    > 99%
  • CAS Number

    69408-81-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    5-Amino-2-[2-(dimethylamino)ethyl]benzo[de]isoquinoline-1,3-dione
  • Molecular weight

    283.33
  • Molecular formula

    C16H17N3O2
  • PubChem identifier

    50515
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C12C=C(C=C3C1=C(C=CC=2)C(N(C3=O)CCN(C)C)=O)N
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Li S  et al. Synthesis, anticancer activity and DNA-binding properties of novel 4-pyrazolyl-1,8-naphthalimide derivatives. Bioorg Med Chem Lett 24:586-90 (2014). Read more (PubMed: 24370011) »
  • Li Y  et al. E2F1-dependent pathways are involved in amonafide analogue 7-d-induced DNA damage, G2/M arrest, and apoptosis in p53-deficient K562 cells. J Cell Biochem 113:3165-77 (2012). Read more (PubMed: 22593008) »
  • Torres Suárez AI & Camacho Sánchez MA Studies about the oral bioavailability of mitonafide and 2HCl amonafide, two new cytotoxic molecules. Farmaco 47:497-508 (1992). Read more (PubMed: 1388597) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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