Overview

  • Product name

    Amoxapine, D2 and 5-HT2 receptor antagonist
  • Description

    Norepinephrine and serotonin reuptake inhibitor. D2 and 5-HT2 receptor antagonist.
  • Biological description

    Norepinephrine and serotonin reuptake inhibitor. D2 and 5-HT2 receptor antagonist. Inhibits rectifier outward K+ currents via a cAMP/PKA-dependent pathway (IC50 = 211.36 μM). Antipsychotic and antidepressant effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    14028-44-5
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Yang G  et al. Amoxapine inhibits delayed outward rectifier K(+) currents in cerebellar granule cells via dopamine receptor and protein kinase A activation. Cell Physiol Biochem 28:163-74 (2011). Read more (PubMed: 21865859) »
  • He YL  et al. Amoxapine inhibits the delayed rectifier outward K+ current in mouse cortical neurons via cAMP/protein kinase A pathways. J Pharmacol Exp Ther 332:437-45 (2010). Read more (PubMed: 19915071) »
  • Obers S  et al. Multiple mechanisms of hERG liability: K+ current inhibition, disruption of protein trafficking, and apoptosis induced by amoxapine. Naunyn Schmiedebergs Arch Pharmacol 381:385-400 (2010). Read more (PubMed: 20229012) »
  • Wadenberg MG  et al. Antipsychoticlike effects of amoxapine, without catalepsy, using the prepulse inhibition of the acoustic startle reflex test in rats. Biol Psychiatry 47:670-6 (2000). Read more (PubMed: 10745061) »

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