Overview

  • Product name

    Anti-AMPD3 antibody [AMPD3/901]
    See all AMPD3 primary antibodies
  • Description

    Mouse monoclonal [AMPD3/901] to AMPD3
  • Host species

    Mouse
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant full length protein corresponding to Human AMPD3.
    Database link: Q01432

  • Positive control

    • IHC-P: Human tonsil and placenta tissues.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    Preservative: 0.05% Sodium azide
    Constituents: PBS, 0.05% BSA
  • Concentration information loading...
  • Purity

    Protein A/G purified
  • Purification notes

    Purified from Bioreactor Concentrate by Protein A/G.
  • Clonality

    Monoclonal
  • Clone number

    AMPD3/901
  • Isotype

    IgG2b
  • Light chain type

    kappa
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab233873 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 2 - 4 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Primary incubation for 30 minutes at RT.

Target

  • Function

    AMP deaminase plays a critical role in energy metabolism.
  • Tissue specificity

    Three isoforms are present in mammals: AMP deaminase 1 is the predominant form in skeletal muscle; AMP deaminase 2 predominates in smooth muscle, non-muscle tissue, embryonic muscle and undifferentiated myoblasts; AMP deaminase 3 is found in erythrocytes.
  • Pathway

    Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.
  • Involvement in disease

    Defects in AMPD3 are the cause of adenosine monophosphate deaminase deficiency erythrocyte type (AMPDDE) [MIM:612874]; also known as erythrocyte AMP deaminase deficiency. AMPDDE is a metabolic disorder due to lack of activity of the erythrocyte isoform of AMP deaminase. It is a clinically asymptomatic condition characterized by a 50% increase in steady-state levels of ATP in affected cells. Individuals with complete deficiency of erythrocyte AMP deaminase are healthy and have no hematologic disorders.
  • Sequence similarities

    Belongs to the adenosine and AMP deaminases family.
  • Information by UniProt
  • Database links

  • Alternative names

    • Adenosine monophosphate deaminase (isoform E) antibody
    • Adenosine monophosphate deaminase 3 antibody
    • AMP aminohydrolase antibody
    • AMP deaminase 3 antibody
    • AMP deaminase isoform E antibody
    • Ampd3 antibody
    • AMPD3_HUMAN antibody
    • Erythrocyte AMP deaminase antibody
    • Erythrocyte specific AMP deaminase antibody
    • Erythrocyte specific protein antibody
    • Erythrocyte type AMP deaminase antibody
    • Erythroid Marker antibody
    • Myoadenylate deaminase antibody
    • OTTHUMP00000230743 antibody
    • OTTHUMP00000230746 antibody
    • OTTHUMP00000230747 antibody
    • OTTHUMP00000230748 antibody
    • OTTHUMP00000230749 antibody
    see all

Images

  • Formalin-fixed, paraffin-embedded human tonsil tissue stained for AMPD3 using ab233873 at 4 µg/ml in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human placenta tissue stained for AMPD3 using ab233873 at 4 µg/ml in immunohistochemical analysis.

References

ab233873 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab233873.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up