Product nameAmphotericin B (aqueous), polyene antifungal antibiotic
DescriptionPolyene antifungal antibiotic.
Polyene antifungal antibiotic originally isolated from Streptomyces sp. that forms channels in fungal membranes inducing non-specific loss of low molecular weight molecules. Binds to sterols and disrupts the osmotic integrity of the fungal membrane.
Storage instructionsStore at +4°C. The product can be stored for up to 12 months.
Solubility overviewSupplied in water (5 mg/ml)
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This product has been referenced in:
- Sundar S et al. Single-dose liposomal amphotericin B for visceral leishmaniasis in India. N Engl J Med 362:504-12 (2010). Read more (PubMed: 20147716) »
- Charak BS et al. Protective effect of granulocyte-colony stimulating factor against amphotericin B-induced myelosuppression in vitro. Br J Haematol 88:693-8 (1994). Read more (PubMed: 7529537) »
- Barth C et al. Inactivation by ionizing radiation of ion channels formed by polyene antibiotics amphotericin B and nystatin in lipid membranes: an inverse dose-rate behavior. Biophys J 64:92-7 (1993). Read more (PubMed: 7679300) »
- Brajtburg J et al. Amphotericin B: current understanding of mechanisms of action. Antimicrob Agents Chemother 34:183-8 (1990). Read more (PubMed: 2183713) »