Amphotericin B (aqueous), polyene antifungal antibiotic (ab146566)

Overview

  • Product name

    Amphotericin B (aqueous), polyene antifungal antibiotic
  • Description

    Polyene antifungal antibiotic.
  • Alternative names

    • Fungizone
  • Biological description

    Polyene antifungal antibiotic originally isolated from Streptomyces sp. that forms channels in fungal membranes inducing non-specific loss of low molecular weight molecules. Binds to sterols and disrupts the osmotic integrity of the fungal membrane.

  • CAS Number

    1397-89-3
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    924.00
  • Molecular formula

    C47H73NO17
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Supplied in water (5 mg/ml)
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Sundar S  et al. Single-dose liposomal amphotericin B for visceral leishmaniasis in India. N Engl J Med 362:504-12 (2010). Read more (PubMed: 20147716) »
  • Charak BS  et al. Protective effect of granulocyte-colony stimulating factor against amphotericin B-induced myelosuppression in vitro. Br J Haematol 88:693-8 (1994). Read more (PubMed: 7529537) »
  • Barth C  et al. Inactivation by ionizing radiation of ion channels formed by polyene antibiotics amphotericin B and nystatin in lipid membranes: an inverse dose-rate behavior. Biophys J 64:92-7 (1993). Read more (PubMed: 7679300) »
  • Brajtburg J  et al. Amphotericin B: current understanding of mechanisms of action. Antimicrob Agents Chemother 34:183-8 (1990). Read more (PubMed: 2183713) »

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