Amrinone, cAMP phosphodiesterase inhibitor (ab142259)

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Overview

  • Product name

    Amrinone, cAMP phosphodiesterase inhibitor

  • Description

    Selective cAMP phosphodiesterase inhibitor. Positive inotropic agent.

  • Biological description

    Selective cAMP phosphodiesterase inhibitor (IC50 values are 5 and 16 μM for 3A and 3B respectively). Positive inotropic agent. Shows anticonvulsive and vasodilatory effects in vivo.

  • Purity

    > 98%

  • CAS Number

    60719-84-8

  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-Amino-5-pyridin-4-yl-1H-pyridin-2-one

  • Molecular weight

    187.20

  • Molecular formula

    C10H9N3O

  • PubChem identifier

    3698

  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.

  • Solubility overview

    Soluble in DMSO

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CN=CC=C1C2=CNC(=O)C(=C2)N

  • Source

    Synthetic

  • Research areas

Associated products

References

This product has been referenced in:

  • Asif M Phosphodiesterase-III Inhibitors Amrinone and Milrinone on Epilepsy and Cardiovascular Activities. N Am J Med Sci 4:499-502 (2012). Read more (PubMed: 23112975) »
  • Tobata D  et al. Effects of dopamine, dobutamine, amrinone and milrinone on regional blood flow in isoflurane anesthetized dogs. J Vet Med Sci 66:1097-105 (2004). Read more (PubMed: 15472474) »
  • Alousi AA & Johnson DC Pharmacology of the bipyridines: amrinone and milrinone. Circulation 73:III10-24 (1986). Read more (PubMed: 2417744) »

Publishing research using ab142259? Please let us know so that we can cite the reference in this datasheet.

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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