Overview

  • Product name
    Amsacrine, DNA topoisomerase II inhibitor
  • Description
    DNA topoisomerase II inhibitor
  • Biological description
    DNA topoisomerase II inhibitor. Antineoplastic agent. Intercalating planar polycyclic aromatic molecule which is active against a number of tumours in mice. Active in vivo.
  • Purity
    > 98%
  • CAS Number
    51264-14-3
  • Chemical structure
    Chemical Structure

Properties

  • Chemical name
    N-[4-(9-Acridinylamino)-3-methoxyphenyl]methanesulfonamide
  • Molecular weight
    393.46
  • Molecular formula
    C21H19N3O3S
  • PubChem identifier
    2179
  • Storage instructions
    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    COC1=C(C=CC(=C1)NS(=O)(=O)C)NC2=C3C=CC=CC3=NC4=CC=CC=C42
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • René B  et al. [Cytotoxicity and interaction of amsacrine derivatives with topoisomerase II: role of the 1' substitute on the aniline nucleus]. Bull Cancer 84:941-8 (1997). Read more (PubMed: 9435795) »
  • Baguley BC The possible role of electron-transfer complexes in the antitumour action of amsacrine analogues. Biophys Chem 35:203-12 (1990). Read more (PubMed: 2204443) »
  • Cassileth PA & Gale RP Amsacrine: a review. Leuk Res 10:1257-65 (1986). Read more (PubMed: 3540460) »
See 1 Publication for this product

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