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Amsacrine, DNA topoisomerase II inhibitor (ab142742)

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Chemical Structure - Amsacrine, DNA topoisomerase II inhibitor (ab142742)

    Key features and details

    • DNA topoisomerase II inhibitor
    • CAS Number: 51264-14-3
    • Purity: > 98%
    • Soluble in DMSO to 100 mM
    • Form / State: Solid
    • Source: Synthetic

    Overview

    • Product name

      Amsacrine, DNA topoisomerase II inhibitor
    • Description

      DNA topoisomerase II inhibitor
    • Biological description

      DNA topoisomerase II inhibitor. Antineoplastic agent. Intercalating planar polycyclic aromatic molecule which is active against a number of tumours in mice. Active in vivo.

    • Purity

      > 98%
    • CAS Number

      51264-14-3
    • Chemical structure

      Chemical Structure

    Properties

    • Chemical name

      N-[4-(9-Acridinylamino)-3-methoxyphenyl]methanesulfonamide
    • Molecular weight

      393.46
    • Molecular formula

      C21H19N3O3S
    • PubChem identifier

      2179
    • Storage instructions

      Store at Room Temperature. The product can be stored for up to 12 months.
    • Solubility overview

      Soluble in DMSO to 100 mM
    • Handling

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      COC1=C(C=CC(=C1)NS(=O)(=O)C)NC2=C3C=CC=CC3=NC4=CC=CC=C42
    • Source

      Synthetic

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    Images

    • Chemical Structure - Amsacrine, DNA topoisomerase II inhibitor (ab142742)
      Chemical Structure - Amsacrine, DNA topoisomerase II inhibitor (ab142742)
      2D chemical structure image of ab142742, Amsacrine, DNA topoisomerase II inhibitor

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download
    • COA

    References (3)

    Publishing research using ab142742? Please let us know so that we can cite the reference in this datasheet.

    ab142742 has been referenced in 3 publications.

    • Schaefer K  et al. In vitro reconstitution demonstrates the cell wall ligase activity of LCP proteins. Nat Chem Biol 13:396-401 (2017). PubMed: 28166208
    • Pasquina L  et al. A synthetic lethal approach for compound and target identification in Staphylococcus aureus. Nat Chem Biol 12:40-5 (2016). PubMed: 26619249
    • Matano LM  et al. Accelerating the discovery of antibacterial compounds using pathway-directed whole cell screening. Bioorg Med Chem 24:6307-6314 (2016). PubMed: 27594549

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