Key features and details
- Endogenous peptide. Potent amylin, calcitonin, CGRP and adrenomedullin receptor agonist.
- CAS Number: 122384-88-7
- Purity: > 95%
- Soluble in water (5 mg/mL)
- Form / State: Solid
- Source: Synthetic
Product nameAmylin (human), Endogenous peptide
DescriptionEndogenous peptide. Potent amylin, calcitonin, CGRP and adrenomedullin receptor agonist.
- Islet amyloid polypeptide (IAPP)
Biological descriptionEndogenous peptide. Potent amylin, calcitonin (EC50 = 0.67 nM), CGRP and adrenomedullin receptor agonist. Potently inhibits insulin-stimulated glucose uptake in skeletal muscle cells (IC50 = 12 pM). Implicated in type II diabetes. Active in vivo. Rat (ab142399) and feline (ab142397) amylin also available.
SequenceKCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY (Modifications: C-terminal amide; Disulfide bonds: 2-7)
Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water (5 mg/mL)
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab142398 has been referenced in 2 publications.
- Majumder P et al. Receptor tyrosine kinases (RTKs) consociate in regulatory clusters in Alzheimer's disease and type 2 diabetes. Mol Cell Biochem 459:171-182 (2019). PubMed: 31154588
- Suzuki H & Yamamoto T Amylin-like immunoreactivity in pancreatic X cells of the black-spotted frog Rana (Pelophylax) nigromaculata. Tissue Cell 46:535-9 (2014). PubMed: 25458814