Overview

  • Product name

    Amylin (rat), Endogenous peptide 
  • Description

    Endogenous peptide secreted by pancreatic β-cells
  • Biological description

    Endogenous peptide secreted by pancreatic β-cells. Potently activates amylin, calcitonin (EC50 = 0.67 nM), CGRP and adrenomedullin receptors. Potently inhibits insulin-stimulated glucose uptake (IC50 = 12 pM). Implicated in type II diabetes. Active in vivo. Human (ab142398) and feline (ab142397) amylin also available.
  • Purity

    > 95%
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Muff R  et al. An amylin receptor is revealed following co-transfection of a calcitonin receptor with receptor activity modifying proteins-1 or -3. Endocrinology 140:2924-7 (1999). Read more (PubMed: 10342886) »
  • Castillo MJ  et al. Amylin/islet amyloid polypeptide: biochemistry, physiology, patho-physiology. Diabete Metab 21:3-25 (1995). Read more (PubMed: 7781840) »
  • Sheriff S  et al. Amylin inhibits insulin-stimulated glucose uptake in C2C12 muscle cell line through a cholera-toxin-sensitive mechanism. Biochim Biophys Acta 1136:219-22 (1992). Read more (PubMed: 1504107) »
  • Zhu GC  et al. Amylin increases cyclic AMP formation in L6 myocytes through calcitonin gene-related peptide receptors. Biochem Biophys Res Commun 177:771-6 (1991). Read more (PubMed: 1646609) »

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