Anti-Amyloid Precursor Protein antibody [Y188] (ab32136)

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ab32136 has been referenced in 54 publications.

  • Xie JC  et al. Hypoxia increases amyloid-ß level in exosomes by enhancing the interaction between CD147 and Hook1. Am J Transl Res 10:150-163 (2018). PubMed: 29423001
  • Xu S  et al. Overexpression of SNX3 Decreases Amyloid-ß Peptide Production by Reducing Internalization of Amyloid Precursor Protein. Neurodegener Dis 18:26-37 (2018). PubMed: 29414832
  • Stoffel W  et al. SMPD3 deficiency perturbs neuronal proteostasis and causes progressive cognitive impairment. Cell Death Dis 9:507 (2018). WB ; Mouse . PubMed: 29725009
  • Peters F  et al. BACE1 inhibition more effectively suppresses initiation than progression of ß-amyloid pathology. Acta Neuropathol 135:695-710 (2018). WB ; Mouse . PubMed: 29327084
  • Birnbaum JH  et al. Oxidative stress and altered mitochondrial protein expression in the absence of amyloid-ß and tau pathology in iPSC-derived neurons from sporadic Alzheimer's disease patients. Stem Cell Res 27:121-130 (2018). WB ; Human . PubMed: 29414602
  • Kulas JA  et al. In utero exposure to fine particulate matter results in an altered neuroimmune phenotype in adult mice. Environ Pollut 241:279-288 (2018). PubMed: 29843010
  • György B  et al. CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer's Disease. Mol Ther Nucleic Acids 11:429-440 (2018). PubMed: 29858078
  • Zhang F  et al. Impacts of Acute Hypoxia on Alzheimer's Disease-Like Pathologies in APPswe/PS1dE9 Mice and Their Wild Type Littermates. Front Neurosci 12:314 (2018). PubMed: 29867325
  • Eggert S  et al. Dimerization leads to changes in APP (amyloid precursor protein) trafficking mediated by LRP1 and SorLA. Cell Mol Life Sci N/A:N/A (2017). PubMed: 28799085
  • Chai Q  et al. HIV-1 counteracts an innate restriction by amyloid precursor protein resulting in neurodegeneration. Nat Commun 8:1522 (2017). PubMed: 29142315
  • Cai H  et al. Neuroprotective effects of bajijiasu against cognitive impairment induced by amyloid-ß in APP/PS1 mice. Oncotarget 8:92621-92634 (2017). PubMed: 29190943
  • Zhang J  et al. Application of FTIR spectroscopy for traumatic axonal injury: a possible tool for estimating injury interval. Biosci Rep 37:N/A (2017). PubMed: 28659494
  • Gowert NS  et al. Loss of Reelin protects mice against arterial thrombosis by impairing integrin activation and thrombus formation under high shear conditions. Cell Signal 40:210-221 (2017). PubMed: 28943410
  • Fisher CL  et al. Cyclic cis-Locked Phospho-Dipeptides Reduce Entry of AßPP into Amyloidogenic Processing Pathway. J Alzheimers Dis 55:391-410 (2017). Human . PubMed: 27662285
  • Vienken H  et al. Characterization of cholesterol homeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts reveals a Niemann-Pick disease type C-like phenotype with enhanced lysosomal Ca(2+) storage. Sci Rep 7:43575 (2017). WB . PubMed: 28262793
  • Poulsen ET  et al. An Aberrant Phosphorylation of Amyloid Precursor Protein Tyrosine Regulates Its Trafficking and the Binding to the Clathrin Endocytic Complex in Neural Stem Cells of Alzheimer's Disease Patients. Front Mol Neurosci 10:59 (2017). IP . PubMed: 28360834
  • Zollo A  et al. Sortilin-Related Receptor Expression in Human Neural Stem Cells Derived from Alzheimer's Disease Patients Carrying the APOE Epsilon 4 Allele. Neural Plast 2017:1892612 (2017). WB, IP, ICC/IF ; Human . PubMed: 28634550
  • Pousinha PA  et al. Physiological and pathophysiological control of synaptic GluN2B-NMDA receptors by the C-terminal domain of amyloid precursor protein. Elife 6:N/A (2017). WB ; Rat . PubMed: 28682239
  • Zhao YL  et al. Rosiglitazone ameliorates diffuse axonal injury by reducing loss of tau and up-regulating caveolin-1 expression. Neural Regen Res 11:944-50 (2016). WB, IHC . PubMed: 27482223
  • Das U  et al. Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway. Nat Neurosci 19:55-64 (2016). PubMed: 26642089
  • Kretner B  et al. Generation and deposition of Aß43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease. EMBO Mol Med 8:458-65 (2016). PubMed: 26988102
  • Lian H  et al. Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease. J Neurosci 36:577-89 (2016). WB, ELISA ; Human . PubMed: 26758846
  • Galambos C  et al. Increased Lung Expression of Anti-Angiogenic Factors in Down Syndrome: Potential Role in Abnormal Lung Vascular Growth and the Risk for Pulmonary Hypertension. PLoS One 11:e0159005 (2016). WB . PubMed: 27487163
  • Huang TY  et al. SNX27 and SORLA Interact to Reduce Amyloidogenic Subcellular Distribution and Processing of Amyloid Precursor Protein. J Neurosci 36:7996-8011 (2016). PubMed: 27466343
  • Manocha GD  et al. APP Regulates Microglial Phenotype in a Mouse Model of Alzheimer's Disease. J Neurosci 36:8471-86 (2016). Mouse . PubMed: 27511018
  • Zhou D  et al. DL0410, a novel dual cholinesterase inhibitor, protects mouse brains against Aß-induced neuronal damage via the Akt/JNK signaling pathway. Acta Pharmacol Sin 37:1401-1412 (2016). PubMed: 27498773
  • Yamaguchi T  et al. Expression of B4GALNT1, an essential glycosyltransferase for the synthesis of complex gangliosides, suppresses BACE1 degradation and modulates APP processing. Sci Rep 6:34505 (2016). PubMed: 27687691
  • Yan X  et al. Ginsenoside Rd. promotes non-amyloidogenic pathway of amyloid precursor protein processing by regulating phosphorylation of estrogen receptor alpha. Life Sci N/A:N/A (2016). PubMed: 27825720
  • Del Turco D  et al. Region-Specific Differences in Amyloid Precursor Protein Expression in the Mouse Hippocampus. Front Mol Neurosci 9:134 (2016). IHC-FrFl ; Mouse . PubMed: 27965537
  • Yetman MJ  et al. Humanized Tau Mice with Regionalized Amyloid Exhibit Behavioral Deficits but No Pathological Interaction. PLoS One 11:e0153724 (2016). PubMed: 27070146
  • Niederst ED  et al. Axonal amyloid precursor protein and its fragments undergo somatodendritic endocytosis and processing. Mol Biol Cell 26:205-17 (2015). PubMed: 25392299
  • Sadleir KR  et al. Aß reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level. Mol Neurodegener 10:1 (2015). PubMed: 25567526
  • Hohsfield LA & Humpel C Intravenous infusion of monocytes isolated from 2-week-old mice enhances clearance of Beta-amyloid plaques in an Alzheimer mouse model. PLoS One 10:e0121930 (2015). WB ; Mouse . PubMed: 25830951
  • Bhatt DP  et al. A pilot study to assess effects of long-term inhalation of airborne particulate matter on early Alzheimer-like changes in the mouse brain. PLoS One 10:e0127102 (2015). PubMed: 25992783
  • Plagg B  et al. Platelet dysfunction in hypercholesterolemia mice, two Alzheimer's disease mouse models and in human patients with Alzheimer's disease. Biogerontology 16:543-58 (2015). WB . PubMed: 25947203
  • Poulsen ET  et al. New Insights to Clathrin and Adaptor Protein 2 for the Design and Development of Therapeutic Strategies. Int J Mol Sci 16:29446-53 (2015). IP . PubMed: 26690411
  • Villegas C  et al. Dual-tagged amyloid-ß precursor protein reveals distinct transport pathways of its N- and C-terminal fragments. Hum Mol Genet 23:1631-43 (2014). PubMed: 24203698
  • Olsen O  et al. Genetic analysis reveals that amyloid precursor protein and death receptor 6 function in the same pathway to control axonal pruning independent of ß-secretase. J Neurosci 34:6438-47 (2014). PubMed: 24806670
  • Durk MR  et al. 1a,25-Dihydroxyvitamin D3 reduces cerebral amyloid-ß accumulation and improves cognition in mouse models of Alzheimer's disease. J Neurosci 34:7091-101 (2014). Mouse . PubMed: 24849345
  • Mota SI  et al. Impaired Src signaling and post-synaptic actin polymerization in Alzheimer's disease mice hippocampus - Linking NMDA receptors and the reelin pathway. Exp Neurol 261:698-709 (2014). Mouse . PubMed: 25128699
  • Del Prete D  et al. APP Is Cleaved by Bace1 in Pre-Synaptic Vesicles and Establishes a Pre-Synaptic Interactome, via Its Intracellular Domain, with Molecular Complexes that Regulate Pre-Synaptic Vesicles Functions. PLoS One 9:e108576 (2014). IHC-FoFr ; Mouse . PubMed: 25247712
  • Chen Y  et al. a(2A) adrenergic receptor promotes amyloidogenesis through disrupting APP-SorLA interaction. Proc Natl Acad Sci U S A 111:17296-301 (2014). PubMed: 25404298
  • Serres S  et al. Magnetic resonance imaging reveals therapeutic effects of interferon-beta on cytokine-induced reactivation of rat model of multiple sclerosis. J Cereb Blood Flow Metab 33:744-53 (2013). Rat . PubMed: 23423190
  • Sosa LJ  et al. Amyloid precursor protein is an autonomous growth cone adhesion molecule engaged in contact guidance. PLoS One 8:e64521 (2013). WB . PubMed: 23691241
  • Wang J  et al. SCG10 promotes non-amyloidogenic processing of amyloid precursor protein by facilitating its trafficking to the cell surface. Hum Mol Genet N/A:N/A (2013). PubMed: 23863461
  • Li S  et al. Temporal profiles of axonal injury following impact acceleration traumatic brain injury in rats--a comparative study with diffusion tensor imaging and morphological analysis. Int J Legal Med 127:159-67 (2013). PubMed: 22573358
  • Rama N  et al. Amyloid Precursor Protein Regulates Netrin-1-mediated Commissural Axon Outgrowth. J Biol Chem 287:30014-23 (2012). IHC-FoFr ; Mouse . PubMed: 22782894
  • Youmans KL  et al. Intraneuronal Aß detection in 5xFAD mice by a new Aß-specific antibody. Mol Neurodegener 7:8 (2012). WB, ICC/IF ; Mouse . PubMed: 22423893
  • Matrone C  et al. APP is phosphorylated by TrkA and regulates NGF/TrkA signaling. J Neurosci 31:11756-61 (2011). PubMed: 21849536
  • Hamilton LK  et al. Widespread deficits in adult neurogenesis precede plaque and tangle formation in the 3xTg mouse model of Alzheimer's disease. Eur J Neurosci 32:905-20 (2010). WB ; Mouse . PubMed: 20726889
  • Mastrangelo MA  et al. Interferon-{gamma} differentially affects Alzheimer's disease pathologies and induces neurogenesis in triple transgenic-AD mice. Am J Pathol 175:2076-88 (2009). FRET, IHC-FoFr ; Mouse . PubMed: 19808651
  • Frazer ME  et al. Reduced pathology and improved behavioral performance in Alzheimer's disease mice vaccinated with HSV amplicons expressing amyloid-beta and interleukin-4. Mol Ther 16:845-53 (2008). PubMed: 18388924
  • Mastrangelo MA & Bowers WJ Detailed immunohistochemical characterization of temporal and spatial progression of Alzheimer's disease-related pathologies in male triple-transgenic mice. BMC Neurosci 9:81 (2008). IHC ; Human . PubMed: 18700006
  • Janelsins MC  et al. Chronic neuron-specific tumor necrosis factor-alpha expression enhances the local inflammatory environment ultimately leading to neuronal death in 3xTg-AD mice. Am J Pathol 173:1768-82 (2008). IHC-FoFr ; Mouse . PubMed: 18974297


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