Product nameAnti-Amyloid Precursor Protein Frameshift Mutant antibody
See all Amyloid Precursor Protein Frameshift Mutant primary antibodies
DescriptionGoat polyclonal to Amyloid Precursor Protein Frameshift Mutant
Tested applicationsSuitable for: ELISA, WB, IHC-Pmore details
Species reactivityReacts with: Human
Synthetic peptide corresponding to Human Amyloid Precursor Protein Frameshift Mutant aa 339-348. Frameshift sequence from Figure 1, van Leeuwen, et.al., Frameshift Mutants of β Amyloid Precursor Protein and Ubiquitin-B in Alzheimer’s and Down Patients, Science, Vol. 279, 9 Jan 1998, 242-247.
Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Mix suspension via gentle inversion before use.
Storage bufferPreservative: 0.1% Sodium azide
Constituent: Whole serum
Defibrinated whole serum
Our Abpromise guarantee covers the use of ab17365 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/3000. Predicted molecular weight: 1 kDa.|
RelevanceAmyloid Precursor Protein (APP) is an integral membrane protein with a large ectodomain, a transmembrane domain, and a short cytoplasmic tail. APP is proteolytically cleaved by b-secretase (BACE) to generate the APP N-terminal fragment (sbAPP) with Mr100kD and a C-terminal fragment (C99) with Mr12kD. The smaller 12kD fragment can be further cleaved by g-secretase, an enzyme activity recently attributed to presenilin-2. This second cleavage produces the insoluble b-amyloid (Ab), a peptide of ~4kD. The accumulation of b-amyloid in intracellular neurofibrillary tangles and extracellular plaques is observed in the brains of Alzheimers disease patients and Downs Syndrome patients.
Cellular localizationCell Membrane, Cytoplasmic, Endoplasmic reticulum and Golgi Apparatus
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