Overview

  • Product name

    Anabaseine, alpha7 nACh receptor agonist
  • Description

    Neurotoxin. Potent, competitive α7 nACh receptor agonist.
  • Biological description

    Neurotoxin. Potent, competitive α7 nACh receptor agonist. Weak, partial α4β2 agonist. GTS-21 dihydrochloride (ab120560) precursor. (R,S)-Anabasine (ab144918) analog. Shows neurotoxic effects in vivo.
  • CAS Number

    3471-05-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-(2,3,4,5-Tetrahydropyridin-6-yl)pyridine
  • Molecular weight

    160.22
  • Molecular formula

    C10H12N2
  • PubChem identifier

    18985
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1CCN=C(C1)C2=CN=CC=C2
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Hu Y  et al. Attenuation of Collagen-Induced Arthritis in rat by nicotinic alpha7 receptor partial agonist GTS-21. Biomed Res Int 2014:325875 (2014). Read more (PubMed: 24719855) »
  • Kem WR  et al. Anabaseine is a potent agonist on muscle and neuronal alpha-bungarotoxin-sensitive nicotinic receptors. J Pharmacol Exp Ther 283:979-92 (1997). Read more (PubMed: 9399967) »
  • Kem WR Alzheimer's drug design based upon an invertebrate toxin (anabaseine) which is a potent nicotinic receptor agonist. Invert Neurosci 3:251-9 (0). Read more (PubMed: 9783447) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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