Overview

  • Product name

    Anagrelide hydrochloride, cAMP PDE-3 inhibitor
  • Description

    Potent cAMP PDE-3 inhibitor
  • Purity

    > 99%
  • CAS Number

    58579-51-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    6,7-Dichloro-5,10-dihydro-3H-imidazo[2,1-b]quinazolin-2-one hydrochloride
  • Molecular weight

    292.55
  • Molecular formula

    C10H7Cl2N3O.HCl
  • PubChem identifier

    42786
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1(=C(C(=C2C(=C1)NC3N(C2)CC(N=3)=O)Cl)Cl).Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Thiele J  et al. Effects of anagrelide on megakaryopoiesis and platelet production. Semin Thromb Hemost 32:352-61 (2006). Read more (PubMed: 16810611) »
  • Lane WJ  et al. Anagrelide metabolite induces thrombocytopenia in mice by inhibiting megakaryocyte maturation without inducing platelet aggregation. Exp Hematol 29:1417-24 (2001). Read more (PubMed: 11750100) »
  • Tefferi A  et al. Anagrelide as a new platelet-lowering agent in essential thrombocythemia: mechanism of actin, efficacy, toxicity, current indications. Semin Thromb Hemost 23:379-83 (1997). Read more (PubMed: 9263355) »

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