Overview

  • Product name

    Anagrelide, PDE3 inhibitor
  • Description

    Potent PDE3 inhibitor
  • Biological description

    Potent PDE3 inhibitor (IC50 = 36 nM). Inhibits megakaryocyte maturation. Inhibits platelet aggregation in vivo. Orally active. Available as anagrelide hydrochloride (ab143306).
  • Purity

    > 98%
  • CAS Number

    68475-42-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    6,7-Dichloro-5,10-dihydro-3H-imidazo[2,1-b]quinazolin-2-one
  • Molecular weight

    256.09
  • Molecular formula

    C10H7Cl2N3O
  • PubChem identifier

    2182
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1C2=C(C=CC(=C2Cl)Cl)NC3=NC(=O)CN31
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Thiele J  et al. Effects of anagrelide on megakaryopoiesis and platelet production. Semin Thromb Hemost 32:352-61 (2006). Read more (PubMed: 16810611) »
  • Venuti MC  et al. Inhibitors of cyclic AMP phosphodiesterase. 3. Synthesis and biological evaluation of pyrido and imidazolyl analogues of 1,2,3,5-tetrahydro-2-oxoimidazo[2,1-b]quinazoline. J Med Chem 31:2136-45 (1988). Read more (PubMed: 2846839) »
  • Baryla UM  et al. The anesthetized ferret, an in vivo model for evaluating inotropic activity: effects of milrinone and anagrelide. J Pharmacol Methods 20:299-306 (1988). Read more (PubMed: 3210682) »

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