Overview

  • Product name

    Andrastin A, PFTase inhibitor
  • Description

    Mycotoxin. PFTase inhibitor.
  • Biological description

    Mycotoxin. PFTase inhibitor. Potently inhibits interaction with P-glycoprotein (IC50 = 100 nM, [3H]azidopine binding in VJ-300 cells). Inhibits the efflux of antitumor agents in drug resistant cells. Increases intracellular accumulation of Vincristine (ab120226).
  • Purity

    > 95%
  • CAS Number

    174232-42-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    Methyl (3S,5R,8S,9R,10S,13R,14R)-3-acetyloxy-10-formyl-4,4,8,12,13,16-hexamethyl-15,17-dioxo-2,3,5,6,7,9-hexahydro-1H-cyclopenta[a]phenanthrene-14-carboxylate
  • Molecular weight

    486.60
  • Molecular formula

    C28H38O7
  • PubChem identifier

    6712564
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol and in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1C(=O)[C@@]2(C(=C[C@@H]3[C@@]([C@@]2(C1=O)C(=O)OC)(CC[C@H]4[C@]3(CC[C@@H](C4(C)C)OC(=O)C)C=O)C)C)C
  • Source

    Aspergillus fumigatus

  • Research areas

References

This product has been referenced in:

  • Fernández-Bodega MA  et al. Proteolytic activity, mycotoxins and andrastin A in Penicillium roqueforti strains isolated from Cabrales, Valdeón and Bejes-Tresviso local varieties of blue-veined cheeses. Int J Food Microbiol 136:18-25 (2009). Read more (PubMed: 19837474) »
  • Overy DP  et al. Andrastin A and barceloneic acid metabolites, protein farnesyl transferase inhibitors from Penicillium albocoremium: chemotaxonomic significance and pathological implications. Mycol Res 109:1243-9 (2005). Read more (PubMed: 16279417) »
  • Rho MC  et al. Enhancement of drug accumulation by andrastin A produced by Penicillium sp. FO-3929 in vincristine-resistant KB cells. J Antibiot (Tokyo) 51:68-72 (1998). Read more (PubMed: 9531989) »

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