Key features and details
- Rabbit polyclonal to Angiogenin
- Suitable for: WB, ICC/IF
- Reacts with: Rat, Human
- Isotype: IgG
Product nameAnti-Angiogenin antibody
See all Angiogenin primary antibodies
DescriptionRabbit polyclonal to Angiogenin
Tested applicationsSuitable for: WB, ICC/IFmore details
Species reactivityReacts with: Rat, Human
Predicted to work with: Mouse
Synthetic peptide corresponding to Human Angiogenin (internal sequence). The immunogen is located within amino acids 70 - 120. 15 amino acid synthetic peptide.
Database link: P03950
- Rat liver tissue lysate. Human Liver Tissue
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at -20°C or -80°C. Avoid freeze / thaw cycle. Store undiluted.
Storage bufferpH: 7.2
Preservative: 0.02% Sodium azide
Constituent: 99% PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab139947 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 17 kDa.|
|ICC/IF||Use a concentration of 20 µg/ml.|
FunctionMay function as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.
Tissue specificityExpressed predominantly in the liver. Also detected in endothelial cells and spinal cord neurons.
Involvement in diseaseDefects in ANG are the cause of susceptibility to amyotrophic lateral sclerosis type 9 (ALS9) [MIM:611895]. ALS is a degenerative disorder of motor neurons in the cortex, brain stem and spinal cord. ALS is characterized by muscular weakness and atrophy.
Sequence similaritiesBelongs to the pancreatic ribonuclease family.
Developmental stageLow level expression in the developing fetus, increased in the neonate, and maximal in the adult.
- Information by UniProt
- ALS9 antibody
- AMYOTROPHIC LATERAL SCLEROSIS antibody
- ANG 1 antibody
ab139947 has been referenced in 4 publications.
- Tu E et al. Dl-3-n-Butylphthalide promotes neovascularization and neurological recovery in a rat model of intracerebral hemorrhage. BMC Neurosci 21:24 (2020). PubMed: 32471341
- Pan L et al. ZNF750 inhibited the malignant progression of oral squamous cell carcinoma by regulating tumor vascular microenvironment. Biomed Pharmacother 105:566-572 (2018). WB . PubMed: 29890464
- Wei HY et al. Puerarin regulates neovascular glaucoma through pigment epithelium-derived growth factor-induced NF-?B signaling pathway. Mol Med Rep 17:7866-7874 (2018). PubMed: 29620183
- Liu S et al. Dynamic expression of chymotrypsin-like elastase 1 over the course of murine lung development. Am J Physiol Lung Cell Mol Physiol 306:L1104-16 (2014). PubMed: 24793170