Anti-Angiogenin antibody (ab214931)
Key features and details
- Sheep polyclonal to Angiogenin
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-Angiogenin antibody
See all Angiogenin primary antibodies -
Description
Sheep polyclonal to Angiogenin -
Host species
Sheep -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Chimpanzee, Gorilla -
Immunogen
Recombinant full length protein corresponding to Human Angiogenin aa 1 to the C-terminus. (Derived from E.coli).
Database link: P03950 -
Positive control
- Human epithelium tissue lysate.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
Constituent: 100% PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Purification notes
The IgG fraction of immunized serum was purified by antigen affinity chromatography. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Isotype control
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Recombinant Protein
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Related Products
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab214931 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/1000 - 1/2000. Detects a band of approximately 16 kDa (predicted molecular weight: 17 kDa).
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Notes |
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WB
1/1000 - 1/2000. Detects a band of approximately 16 kDa (predicted molecular weight: 17 kDa). |
Target
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Function
May function as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo. -
Tissue specificity
Expressed predominantly in the liver. Also detected in endothelial cells and spinal cord neurons. -
Involvement in disease
Defects in ANG are the cause of susceptibility to amyotrophic lateral sclerosis type 9 (ALS9) [MIM:611895]. ALS is a degenerative disorder of motor neurons in the cortex, brain stem and spinal cord. ALS is characterized by muscular weakness and atrophy. -
Sequence similarities
Belongs to the pancreatic ribonuclease family. -
Developmental stage
Low level expression in the developing fetus, increased in the neonate, and maximal in the adult. -
Cellular localization
Secreted. - Information by UniProt
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Database links
- Entrez Gene: 494026 Chimpanzee
- Entrez Gene: 283 Human
- Omim: 105850 Human
- SwissProt: Q8WME8 Chimpanzee
- SwissProt: Q71MJ0 Gorilla
- SwissProt: P03950 Human
- Unigene: 283749 Human
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Alternative names
- ALS9 antibody
- AMYOTROPHIC LATERAL SCLEROSIS antibody
- ANG 1 antibody
see all
Images
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Anti-Angiogenin antibody (ab214931) at 1/1000 dilution + Human epithelium tissue lysate
Predicted band size: 17 kDa
Observed band size: 16 kDa why is the actual band size different from the predicted?
Datasheets and documents
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Datasheet download
References (0)
ab214931 has not yet been referenced specifically in any publications.