Overview

  • Product name

    Anti-Angiogenin antibody [EPR18233-116]
    See all Angiogenin primary antibodies
  • Description

    Rabbit monoclonal [EPR18233-116] to Angiogenin
  • Host species

    Rabbit
  • Tested applications

    Suitable for: Sandwich ELISAmore details
  • Species reactivity

    Reacts with: Mouse
  • Immunogen

    The details of the immunogen for this antibody are not available.

  • General notes

    Anti-Angiogenin antibody (ab222525) is used in our 90-minute ELISA kit, Human Angiogenin ELISA kit (ab208349), and available in the matched antibody pair kit (ab215073).

Properties

Applications

Our Abpromise guarantee covers the use of ab222525 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Sandwich ELISA Use at an assay dependent concentration.

Target

  • Function

    May function as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.
  • Tissue specificity

    Expressed predominantly in the liver. Also detected in endothelial cells and spinal cord neurons.
  • Involvement in disease

    Defects in ANG are the cause of susceptibility to amyotrophic lateral sclerosis type 9 (ALS9) [MIM:611895]. ALS is a degenerative disorder of motor neurons in the cortex, brain stem and spinal cord. ALS is characterized by muscular weakness and atrophy.
  • Sequence similarities

    Belongs to the pancreatic ribonuclease family.
  • Developmental stage

    Low level expression in the developing fetus, increased in the neonate, and maximal in the adult.
  • Cellular localization

    Secreted.
  • Information by UniProt
  • Database links

  • Alternative names

    • ALS9 antibody
    • AMYOTROPHIC LATERAL SCLEROSIS antibody
    • ANG 1 antibody
    • ANG antibody
    • ANG I antibody
    • ANG1 antibody
    • ANGI antibody
    • ANGI_HUMAN antibody
    • Angiogenin antibody
    • Angiogenin ribonuclease RNase A family, 5 antibody
    • Epididymis luminal protein 168 antibody
    • HEL168 antibody
    • MGC22466 antibody
    • MGC71966 antibody
    • Ribonuclease 5 antibody
    • Ribonuclease RNase A Family 5 antibody
    • RNase 5 antibody
    • RNASE4 antibody
    • RNASE5 antibody
    see all

Images

  • Example of mouse Angiogenin standard curve in 1X Cell Extraction Buffer PTR using recombinant Angiogenin RabMAb antibody (ab222525) and a recombinant monoclonal antibody. Background-subtracted values (mean +/- SD) are graphed.

    For a complete ELISA kit, see Mouse Angiogenin ELISA kit (ab208349).

    For a matched antibody pair set, see Mouse Angiogenin Matched Antibody Pair Kit (ab215073).

References

ab222525 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab222525.
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