Key features and details
- Rabbit polyclonal to Angiopoietin 2/ANG2
- Suitable for: ICC, WB
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
Product nameAnti-Angiopoietin 2/ANG2 antibody
See all Angiopoietin 2/ANG2 primary antibodies
DescriptionRabbit polyclonal to Angiopoietin 2/ANG2
SpecificityAt least three isoforms of ANGPT2 are known to exist; this antibody will detect all three isoforms.
Tested applicationsSuitable for: ICC, WBmore details
Species reactivityReacts with: Mouse, Rat, Human
Synthetic peptide corresponding to Human Angiopoietin 2/ANG2 (C terminal).
(Peptide available as
- Human Liver Tissue Lysate.
This product was previously labelled as Angiopoietin 2
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferPreservative: 0.02% Sodium azide
Constituent: 99% PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab125692 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|ICC||Use a concentration of 2.5 µg/ml.|
|WB||Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 56 kDa.|
FunctionCan induce tyrosine phosphorylation of TIE2. Binds to TIE2 receptor and counteracts blood vessel maturation/stability mediated by angiopoietin-1. Its function may be context-dependent. In the absence of angiogenic inducers, such as VEGF, ANG2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.
Sequence similaritiesContains 1 fibrinogen C-terminal domain.
DomainThe Fibrinogen C-terminal domain mediates interaction with the TEK/TIE2 receptor.
- Information by UniProt
- AGPT 2 antibody
- Agpt2 antibody
- ANG 2 antibody
Lane 1 : Anti-Angiopoietin 2/ANG2 antibody (ab125692) at 1 µg/ml
Lane 2 : Anti-Angiopoietin 2/ANG2 antibody (ab125692) at 2 µg/ml
All lanes : Human liver tissue lysate
Lysates/proteins at 15 µg per lane.
Predicted band size: 56 kDa
Immunohistochemistry of Angiopoietin 2/ANG2 in mouse liver tissue with ab125692 antibody at 2.5 ug/mL.
ab125692 has been referenced in 1 publication.
- Zhan Y et al. An MRI Study of Neurovascular Restorative After Combination Treatment With Xiaoshuan Enteric-Coated Capsule and Enriched Environment in Rats After Stroke. Front Neurosci 13:701 (2019). PubMed: 31354412