Overview

  • Product name

    Anti-Angiopoietin 2/ANG2 antibody
    See all Angiopoietin 2/ANG2 primary antibodies
  • Description

    Rabbit polyclonal to Angiopoietin 2/ANG2
  • Host species

    Rabbit
  • Specificity

    At least three isoforms of ANGPT2 are known to exist; this antibody will detect all three isoforms.
  • Tested applications

    Suitable for: ICC, WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human Angiopoietin 2/ANG2 (C terminal).
    (Peptide available as ab172727)

  • Positive control

    • Human Liver Tissue Lysate.
  • General notes

     This product was previously labelled as Angiopoietin 2

     

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer

    Preservative: 0.02% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab125692 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC Use a concentration of 2.5 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 56 kDa.

Target

  • Function

    Can induce tyrosine phosphorylation of TIE2. Binds to TIE2 receptor and counteracts blood vessel maturation/stability mediated by angiopoietin-1. Its function may be context-dependent. In the absence of angiogenic inducers, such as VEGF, ANG2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.
  • Sequence similarities

    Contains 1 fibrinogen C-terminal domain.
  • Domain

    The Fibrinogen C-terminal domain mediates interaction with the TEK/TIE2 receptor.
  • Cellular localization

    Secreted.
  • Information by UniProt
  • Database links

  • Alternative names

    • AGPT 2 antibody
    • Agpt2 antibody
    • ANG 2 antibody
    • ANG-2 antibody
    • ANG2 antibody
    • Angiopoietin 2a antibody
    • Angiopoietin 2B antibody
    • Angiopoietin-2 antibody
    • Angiopoietin2 antibody
    • ANGP2_HUMAN antibody
    • ANGPT 2 antibody
    • Angpt2 antibody
    • Tie2 ligand antibody
    see all

Images

  • Lane 1 : Anti-Angiopoietin 2/ANG2 antibody (ab125692) at 1 µg/ml
    Lane 2 : Anti-Angiopoietin 2/ANG2 antibody (ab125692) at 2 µg/ml

    All lanes : Human liver tissue lysate

    Lysates/proteins at 15 µg per lane.

    Predicted band size: 56 kDa

  • Immunohistochemistry of Angiopoietin 2/ANG2 in mouse liver tissue with ab125692 antibody at 2.5 ug/mL.

References

ab125692 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab125692.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up