• Product name
    Anti-Angiopoietin-like 4 antibody
    See all Angiopoietin-like 4 primary antibodies
  • Description
    Rabbit polyclonal to Angiopoietin-like 4
  • Host species
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to an internal sequence of Human ARP4.

  • Positive control
    • Breast cancer tissue.



Our Abpromise guarantee covers the use of ab115798 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 45 kDa.Can be blocked with Angiopoietin-like 4 peptide (ab123817).

The detection limit for Angiopoietin-like 4 is approximately 2.5ng/lane under non-reducing and reducing conditions.

IHC-P Use a concentration of 1 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.


  • Function
    Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorgenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation.
  • Tissue specificity
    Expressed at high levels in the placenta, heart, liver, muscle, pancreas and lung but expressed poorly in the brain and kidney.
  • Sequence similarities
    Contains 1 fibrinogen C-terminal domain.
  • Post-translational
  • Cellular localization
    Secreted. Secreted > extracellular space > extracellular matrix. The unprocessed form interacts with the extracellular matrix. This may constitute a dynamic reservoir, a regulatory mechanism of the bioavailability of ANGPTL4.
  • Information by UniProt
  • Database links
  • Alternative names
    • Angiopoietin like 4 antibody
    • Angiopoietin related protein 4 antibody
    • Angiopoietin-like protein 4 antibody
    • Angiopoietin-related protein 4 antibody
    • ANGL4_HUMAN antibody
    • ANGPT L2 antibody
    • ANGPT L4 antibody
    • ANGPTL2 antibody
    • Angptl4 antibody
    • ARP4 antibody
    • Fasting induced adipose factor antibody
    • FIAF antibody
    • HARP antibody
    • Hepatic angiopoietin related protein antibody
    • Hepatic fibrinogen/angiopoietin related protein antibody
    • Hepatic fibrinogen/angiopoietin-related protein antibody
    • HFARP antibody
    • NL2 antibody
    • Peroxisome proliferator-activated receptor (PPAR) gamma induced angiopoietin related protein antibody
    • PGAR antibody
    • pp1158 antibody
    • PPARG angiopoietin related protein antibody
    • PSEC0166 antibody
    • TGQTL antibody
    • UNQ171 antibody
    • Weakly similar to angiopoietin 1 [H.sapiens] antibody
    see all


  • ab115798 at 1µg/ml staining Angiopoietin-like 4 in by Paraffin-embedded Human breast cancer tissue by Immunohistochemistry,

  • All lanes : Anti-Angiopoietin-like 4 antibody (ab115798)

    Lane 1 : Smmc Whole Cell Lysate
    Lane 2 : A549 Whole Cell Lysate
    Lane 3 : U87 Whole Cell Lysate
    Lane 4 : 293T Whole Cell Lysate
    Lane 5 : SGC Whole Cell Lysate

    Predicted band size: 45 kDa


This product has been referenced in:
  • Li B  et al. TGF-ß2-induced ANGPTL4 expression promotes tumor progression and osteoclast differentiation in giant cell tumor of bone. Oncotarget 8:54966-54977 (2017). Read more (PubMed: 28903395) »
  • Florea V  et al. c-Myc Is Essential to Prevent Endothelial Pro-Inflammatory Senescent Phenotype. PLoS One 8:e73146 (2013). WB . Read more (PubMed: 24039874) »

See all 2 Publications for this product

Customer reviews and Q&As

Thank you for contacting us.  We have added the blocking peptide for ab115798 to our catalog.  It is now listed as Angiopoietin-like 4 peptide - ab123817.  The lead time for this peptide is currently 3-4 weeks.  I hope this helps, please let me know if...

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