• Product name
    Anti-Angiopoietin-like 4 antibody
    See all Angiopoietin-like 4 primary antibodies
  • Description
    Rabbit polyclonal to Angiopoietin-like 4
  • Host species
  • Specificity
    This antibody is specific for ARP4.
  • Tested applications
    Suitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant human ARP4. 25 kDa protein containing 204 amino acid residues of the human ARP4 and 16 additional amino acid residues, HisTag. Source of immunogen, E. coli



Our Abpromise guarantee covers the use of ab47046 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent dilution.
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 45 kDa.


  • Function
    Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorgenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation.
  • Tissue specificity
    Expressed at high levels in the placenta, heart, liver, muscle, pancreas and lung but expressed poorly in the brain and kidney.
  • Sequence similarities
    Contains 1 fibrinogen C-terminal domain.
  • Post-translational
  • Cellular localization
    Secreted. Secreted > extracellular space > extracellular matrix. The unprocessed form interacts with the extracellular matrix. This may constitute a dynamic reservoir, a regulatory mechanism of the bioavailability of ANGPTL4.
  • Information by UniProt
  • Database links
  • Alternative names
    • Angiopoietin like 4 antibody
    • Angiopoietin related protein 4 antibody
    • Angiopoietin-like protein 4 antibody
    • Angiopoietin-related protein 4 antibody
    • ANGL4_HUMAN antibody
    • ANGPT L2 antibody
    • ANGPT L4 antibody
    • ANGPTL2 antibody
    • Angptl4 antibody
    • ARP4 antibody
    • Fasting induced adipose factor antibody
    • FIAF antibody
    • HARP antibody
    • Hepatic angiopoietin related protein antibody
    • Hepatic fibrinogen/angiopoietin related protein antibody
    • Hepatic fibrinogen/angiopoietin-related protein antibody
    • HFARP antibody
    • NL2 antibody
    • Peroxisome proliferator-activated receptor (PPAR) gamma induced angiopoietin related protein antibody
    • PGAR antibody
    • pp1158 antibody
    • PPARG angiopoietin related protein antibody
    • PSEC0166 antibody
    • TGQTL antibody
    • UNQ171 antibody
    • Weakly similar to angiopoietin 1 [H.sapiens] antibody
    see all


  • All lanes : Anti-Angiopoietin-like 4 antibody (ab47046) at 1 µg/ml

    Lane 1 : Recombinant protein 100 ng/Lane, Reducing
    Lane 2 : Recombinant protein 10 ng/Lane, Reducing
    Lane 3 : Recombinant protein 1 ng/Lane, Reducing
    Lane 4 : Recombinant protein 1 ng/Lane, Non-Reducing
    Lane 5 : Recombinant protein 10 ng/Lane, Non-Reducing
    Lane 6 : Recombinant protein 100 ng/Lane, Non-Reducing

    All lanes : Anti-Rabbit HRP-Conjugate at 1/2000 dilution

    Predicted band size: 45 kDa


This product has been referenced in:
  • Inoue T  et al. Cross-enhancement of ANGPTL4 transcription by HIF1 alpha and PPAR beta/delta is the result of the conformational proximity of two response elements. Genome Biol 15:R63 (2014). Read more (PubMed: 24721177) »

See 1 Publication for this product

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