Key features and details
- Rabbit polyclonal to Angiotensin Converting Enzyme 1
- Suitable for: IHC-P, WB
- Reacts with: Mouse, Rat
- Isotype: IgG
Product nameAnti-Angiotensin Converting Enzyme 1 antibody
See all Angiotensin Converting Enzyme 1 primary antibodies
DescriptionRabbit polyclonal to Angiotensin Converting Enzyme 1
Tested applicationsSuitable for: IHC-P, WBmore details
Species reactivityReacts with: Mouse, Rat
Predicted to work with: Cat, Human
Synthetic peptide within Cat Angiotensin Converting Enzyme 1 aa 690-740 conjugated to keyhole limpet haemocyanin. The exact sequence is proprietary.
Database link: 101094061
- IHC-P: Rat pancreas tissue. WB: Mouse lung, liver and adrenal lysate.
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferPreservative: 0.09% Sodium azide
Constituents: 50% Glycerol, 1% BSA
Concentration information loading...
PurityProtein A purified
Our Abpromise guarantee covers the use of ab216476 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/100 - 1/500.|
|WB||1/100 - 1/1000. Predicted molecular weight: 150 kDa.|
FunctionConverts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety.
Tissue specificityUbiquitously expressed, with highest levels in lung, kidney, heart, gastrointestinal system and prostate. Isoform Testis-specific is expressed in spermatocytes and adult testis.
Involvement in diseaseIschemic stroke (ISCHSTR) [MIM:601367]: A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
Renal tubular dysgenesis (RTD) [MIM:267430]: Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype). Note=The disease is caused by mutations affecting the gene represented in this entry.
Microvascular complications of diabetes 3 (MVCD3) [MIM:612624]: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
Intracerebral hemorrhage (ICH) [MIM:614519]: A pathological condition characterized by bleeding into one or both cerebral hemispheres including the basal ganglia and the cerebral cortex. It is often associated with hypertension and craniocerebral trauma. Intracerebral bleeding is a common cause of stroke. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
Sequence similaritiesBelongs to the peptidase M2 family.
modificationsPhosphorylated by CK2 on Ser-1299; which allows membrane retention.
Cellular localizationSecreted and Cell membrane.
- Information by UniProt
- ACE 1 antibody
- ACE antibody
- ACE T antibody
Immunohistochemical analysis of formalin-fixed paraffin-embedded rat pancreas tissue sections labeling Angiotensin Converting Enzyme 1 with ab216476 at a 1/200 dilution. DAB staining.
All lanes : Anti-Angiotensin Converting Enzyme 1 antibody (ab216476) at 1/300 dilution
Lane 1 : Mouse lung lysates
Lane 2 : Mouse liver lysates
Lane 3 : Mouse adrenal lysates
All lanes : Goat anti-rabbit IgG (H+L), HRP conjugated at 1/5000 dilution
Predicted band size: 150 kDa
ab216476 has been referenced in 1 publication.
- Zhu Y et al. The Effect and Mechanism of Chinese Herbal Formula Sini Tang in Heart Failure after Myocardial Infarction in Rats. Evid Based Complement Alternat Med 2018:5629342 (2018). PubMed: 30050591