Product nameAngiotensin II (human), Vasoconstrictor peptide
Biological descriptionEndogenous peptide involved in body water and electrolyte homeostasis, blood pressure, cyclicity of reproductive hormones and sexual behaviours, and the regulation of pituitary gland hormones.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 1mg/ml
This product is supplied in one (or more) pack size which is freeze dried. Therefore the contents may not be readily visible, as they can coat the bottom or walls of the vial. Please see our FAQs and information page for more details on handling.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipid metabolism
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab120183 has been referenced in 10 publications.
- Bao Q et al. Intermittent hypoxia mediated by TSP1 dependent on STAT3 induces cardiac fibroblast activation and cardiac fibrosis. Elife 9:N/A (2020). PubMed: 31934850
- Yang S et al. The role of STAT3/mTOR-regulated autophagy in angiotensin II-induced senescence of human glomerular mesangial cells. Cell Signal 53:327-338 (2019). PubMed: 30389500
- Duan J et al. The cell-wide web coordinates cellular processes by directing site-specific Ca2+ flux across cytoplasmic nanocourses. Nat Commun 10:2299 (2019). PubMed: 31127110
- Wang Z et al. Metformin represses the pathophysiology of AAA by suppressing the activation of PI3K/AKT/mTOR/autophagy pathway in ApoE-/- mice. Cell Biosci 9:68 (2019). PubMed: 31467666
- Ageeva LV et al. Data supporting that adipose-derived mesenchymal stem/stromal cells express angiotensin II receptors in situ and in vitro. Data Brief 16:327-333 (2018). PubMed: 29234689
- Li Q et al. Megalin mediates plasma membrane to mitochondria cross-talk and regulates mitochondrial metabolism. Cell Mol Life Sci 75:4021-4040 (2018). PubMed: 29916093
- Yang L et al. Effect of AMPK signal pathway on pathogenesis of abdominal aortic aneurysms. Oncotarget 8:92827-92840 (2017). PubMed: 29190959
- Sysoeva VY et al. Local angiotensin II promotes adipogenic differentiation of human adipose tissue mesenchymal stem cells through type 2 angiotensin receptor. Stem Cell Res 25:115-122 (2017). PubMed: 29127873
- Yang L et al. Silencing of hypoxia inducible factor-1a gene attenuated angiotensin ?-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice. Atherosclerosis 252:40-49 (2016). PubMed: 27497884
- Yu C et al. Knockdown of angiopoietin like-2 protects against angiotensin II-induced cerebral endothelial dysfunction in mice. Am J Physiol Heart Circ Physiol 308:H386-97 (2015). PubMed: 25527773