Product nameAngiotensin II Type 1 Receptor peptide
See all Angiotensin II Type 1 Receptor proteins and peptides
Our Abpromise guarantee covers the use of ab176148 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-Angiotensin II Type 1 Receptor antibody (ab124505)
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Preparation and Storage
Stability and Storage
Store at -20°C.
- Agtr 1
FunctionReceptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Tissue specificityLiver, lung, adrenal and adrenocortical adenomas.
Involvement in diseaseDefects in AGTR1 are a cause of renal tubular dysgenesis (RTD) [MIM:267430]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).
Sequence similaritiesBelongs to the G-protein coupled receptor 1 family.
modificationsC-terminal Ser or Thr residues may be phosphorylated.
Cellular localizationCell membrane.
- Information by UniProt
ab176148 has not yet been referenced specifically in any publications.