Angiotensin III (human, mouse), Endogenous angiotensin receptor peptide (ab141805)

Overview

  • Product name

    Angiotensin III (human, mouse), Endogenous angiotensin receptor peptide
  • Description

    Endogenous angiotensin receptor peptide
  • Biological description

    Endogenous angiotensin receptor peptide. Displays the same affinity for AT1 and AT2 receptors as Angiotensin II (Asc 183) but also binds to non-AT1/AT2 receptors. Shows antihypertenisve effects and induces aldosterone release in vivo.
  • Purity

    > 98%
  • CAS Number

    13602-53-4
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    931.10
  • Molecular formula

    C46H66N12O9
  • Sequence

    RVYIHPF
  • PubChem identifier

    3082042
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)O)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)N
  • Source

    Synthetic

  • Research areas

Images

  • Angiotensin III induces MAPK activation in IEC-6 cells similar to Angiotensin II.

    Cells were incubated in serum depleted medium for 2 h and then stimulated with 0.1 µM and 1 µM Angiotensin III (ab141805) for 10 min or with 0.1 µM and 1 µM Angiotensin II (ab120183) for comparison. Cell proteins were resolved by SDS-PAGE and probed with anti-phospo-ERK1/2.

References

This product has been referenced in:

  • Yugandhar VG & Clark MA Angiotensin III: A physiological relevant peptide of the renin angiotensin system. Peptides 46:26-32 (2013). Read more (PubMed: 23692861) »
  • Yatabe J  et al. Angiotensin III stimulates aldosterone secretion from adrenal gland partially via angiotensin II type 2 receptor but not angiotensin II type 1 receptor. Endocrinology 152:1582-8 (2011). Read more (PubMed: 21303953) »
  • Reaux-Le Goazigo A  et al. Role of angiotensin III in hypertension. Curr Hypertens Rep 7:128-34 (2005). Read more (PubMed: 15748538) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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