Anhydrotetracycline hydrochloride, Tetracycline repressor (ab145350)

Overview

  • Product name

    Anhydrotetracycline hydrochloride, Tetracycline repressor
  • Description

    Tetracycline repressor and reverse tetracycline repressor effector
  • Biological description

    Tetracycline repressor and reverse tetracycline repressor effector. Tetracycline (ab141223, ab146579) derivative. Tetracycline-dependent gene expression effector in bacterial expression systems. Binds poorly to the 30S ribosomal subunit. Exhibits no antibiotic activity.
  • Purity

    > 98%
  • CAS Number

    13803-65-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (4S,4aS,12aS)-4-(Dimethylamino)-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-1,4,4a,5,12,12a-hexahydro-2-tetracenecarboxamide hydrochloride
  • Molecular weight

    462.88
  • Molecular formula

    C22H22N2O7.HCl
  • PubChem identifier

    54710409
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    Cl.NC(=O)C3=C(O)[C@@H](N(C)C)[C@@H]4Cc2c(c(O)c1c(O)cccc1c2C)C(=O)[C@]4(O)C3=O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Werten S  et al. Tetracycline repressor allostery does not depend on divalent metal recognition. Biochemistry 53:7990-8 (2014). Read more (PubMed: 25432019) »
  • Dong H  et al. Development of an anhydrotetracycline-inducible gene expression system for solvent-producing Clostridium acetobutylicum: A useful tool for strain engineering. Metab Eng 14:59-67 (2012). Read more (PubMed: 22056607) »
  • Ehrt S  et al. Controlling gene expression in mycobacteria with anhydrotetracycline and Tet repressor. Nucleic Acids Res 33:e21 (2005). Read more (PubMed: 15687379) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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