Overview

  • Product name

  • Description

    Rabbit polyclonal to ANKS1B
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Chicken, Cow, Dog, Pig, Zebrafish
  • Immunogen

    Synthetic peptide corresponding to a region within C terminal amino acids 459-508 (PSKPIPKPRV SIRKSVQIDP SEQKTLANLP WIVEPGQEAK RGINTKYETT) of Human ANKS1B (NP_858056).

  • Positive control

    • HepG2 cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab133829 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 58 kDa.

Target

  • Function

    Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells.
    Isoform 3 can regulate global protein synthesis by altering nucleolar numbers.
    Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing.
  • Tissue specificity

    Highly expressed in marrow from patients with pre-B ALL associated with the t(1;19) translocation. Strongly expressed in brain and testis. Expressed in fetal brain. Isoform 4 is highly expressed in brain (at protein level). Isoform 6 is expressed in brain and several cancer cell lines.
  • Sequence similarities

    Contains 7 ANK repeats.
    Contains 1 PID domain.
    Contains 2 SAM (sterile alpha motif) domains.
  • Post-translational
    modifications

    Isoform 3 nuclear translocation requires an NMDAR-dependent proteolytic cleavage.
  • Cellular localization

    Cytoplasm; Nucleus; Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Cell projection > dendritic spine. Nucleus. Nucleus > Cajal body. The synaptic localization requires DLG4 interaction. Translocation to the nucleus in response to stimulation of NMDA receptors (NMDARs) in a calcium-independent manner and Nucleus. The interaction with APP causes its partial exclusion from the nucleus, when APP is overexpressed.
  • Information by UniProt
  • Database links

  • Alternative names

    • AIDA antibody
    • AIDA-1 antibody
    • Amyloid-beta protein intracellular domain-associated protein 1 antibody
    • Anks1b antibody
    • ANKS2 antibody
    • Ankyrin repeat and sterile alpha motif domain containing 1B antibody
    • Ankyrin repeat and sterile alpha motif domain-containing protein 1B antibody
    • ANS1B_HUMAN antibody
    • Cajalin 2 antibody
    • E2A-PBX1-associated protein antibody
    • EB-1 antibody
    • EB1 antibody
    • MGC26087 antibody
    see all

Images

  • Anti-ANKS1B antibody (ab133829) at 1 µg/ml + HepG2 cell lysate at 10 µg

    Predicted band size: 58 kDa

References

ab133829 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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