Overview

  • Product name

  • Description

    Rabbit polyclonal to anoctamin 5
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-P, ELISAmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide within Human anoctamin 5 (N terminal). The exact sequence is proprietary.
    Database link: Q75V66

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Purity

    Whole antiserum
  • Clonality

    Polyclonal
  • Isotype

    IgG

Applications

Our Abpromise guarantee covers the use of ab181663 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/2000. Predicted molecular weight: 107 kDa.
IHC-P 1/50 - 1/500.
ELISA Use at an assay dependent concentration.

Target

  • Function

    May act as a calcium-activated chloride channel.
  • Tissue specificity

    Highly expressed in brain, heart, kidney, lung, and skeletal muscle. Weakly expressed in bone marrow, fetal liver, placenta, spleen, thymus, osteoblasts and periodontal ligament cells.
  • Involvement in disease

    Defects in ANO5 are the cause of gnathodiaphyseal dysplasia (GDD) [MIM:166260]; also known as osteogenesis imperfecta with unusual skeletal lesions or gnathodiaphyseal sclerosis. GDD is a rare skeletal syndrome characterized by bone fragility, sclerosis of tubular bones, and cemento-osseous lesions of the jawbone. Patients experience frequent bone fractures caused by trivial accidents in childhood; however the fractures heal normally without bone deformity. The jaw lesions replace the tooth-bearing segments of the maxilla and mandible with fibrous connective tissues, including various amounts of cementum-like calcified mass, sometimes causing facial deformities. Patients also have a propensity for jaw infection and often suffer from purulent osteomyelitis-like symptoms, such as swelling of and pus discharge from the gums, mobility of the teeth, insufficient healing after tooth extraction and exposure of the lesions into the oral cavity.
    Defects in ANO5 are the cause of limb-girdle muscular dystrophy type 2L (LGMD2L) [MIM:611307]. It is an autosomal recessive degenerative myopathy characterized by proximal weakness, weakness of the hip and shoulder girdles and prominent asymmetrical quadriceps femoris and biceps brachii atrophy.
    Defects in ANO5 are the cause of miyoshi muscular dystrophy type 3 (MMD3) [MIM:613319]. It is a late-onset muscular dystrophy characterized by distal muscle weakness of the lower limbs, calf muscle discomfort and weakness, quadriceps atrophy. Muscle weakness and atrophy may be asymmetric.
  • Sequence similarities

    Belongs to the anoctamin family.
  • Cellular localization

    Endoplasmic reticulum membrane. Co-localized with CALR/calreticulin.
  • Information by UniProt
  • Database links

  • Alternative names

    • Ano5 antibody
    • ANO5_HUMAN antibody
    • Anoctamin-5 antibody
    • GDD1 antibody
    • Gnathodiaphyseal dysplasia 1 protein antibody
    • Integral membrane protein GDD1 antibody
    • LGMD2L antibody
    • Limb girdle muscular dystrophy 2L (autosomal recessive) antibody
    • TMEM16E antibody
    • Transmembrane protein 16E antibody
    see all

References

ab181663 has not yet been referenced specifically in any publications.

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