Key features and details
- Potent microtubule depolymerizing agent
- CAS Number: 66547-09-9
- Purity: > 95%
- Soluble in DMSO
- Form / State: Solid
- Source: Synthetic
Product nameAnsamitocin P-3, microtubule depolymerizing agent
DescriptionPotent microtubule depolymerizing agent
Biological descriptionPotent microtubule depolymerizing agent. Binds to tubulin at the vinblastine (ab145649) site. Induces p53-mediated apoptosis. Shows cytotoxic effects to tumor cell lines. Maytansine analog. Shows antitumor effects in vivo. Orally active.
Chemical name3-De(2-(acetylmethylamino)propionyloxy)-3-hydroxymaytansine butyrate
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab144546 has been referenced in 2 publications.
- Hayashi H & Akiyoshi B Degradation of cyclin B is critical for nuclear division in Trypanosoma brucei. Biol Open 7:N/A (2018). PubMed: 29530930
- Llauró A et al. The kinetoplastid kinetochore protein KKT4 is an unconventional microtubule tip-coupling protein. J Cell Biol 217:3886-3900 (2018). PubMed: 30209069