Ansamitocin P-3, microtubule depolymerizing agent (ab144546)

Overview

  • Product name

    Ansamitocin P-3, microtubule depolymerizing agent
  • Description

    Potent microtubule depolymerizing agent
  • Biological description

    Potent microtubule depolymerizing agent. Binds to tubulin at the vinblastine (ab145649) site. Induces p53-mediated apoptosis. Shows cytotoxic effects to tumor cell lines. Maytansine analog. Shows antitumor effects in vivo. Orally active.
  • Purity

    > 95%
  • CAS Number

    66547-09-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-De(2-(acetylmethylamino)propionyloxy)-3-hydroxymaytansine butyrate
  • Molecular weight

    635.20
  • Molecular formula

    C32H43ClN2O9
  • PubChem identifier

    5282049
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C[C@@H]1[C@@H]2C[C@]([C@@H](/C=C/C=C(/CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)C[C@@H]([C@]4([C@H]1O4)C)OC(=O)C(C)C)C)\C)OC)(NC(=O)O2)O
  • Source

    Synthetic

References

This product has been referenced in:

  • Venghateri JB  et al. Ansamitocin P3 depolymerizes microtubules and induces apoptosis by binding to tubulin at the vinblastine site. PLoS One 8:e75182 (2013). Read more (PubMed: 24124473) »
  • Saradhi UV  et al. Characterization of silvestrol pharmacokinetics in mice using liquid chromatography-tandem mass spectrometry. AAPS J 13:347-56 (2011). Read more (PubMed: 21499689) »
  • Liu Z  et al. Metabolism studies of the anti-tumor agent maytansine and its analog ansamitocin P-3 using liquid chromatography/tandem mass spectrometry. J Mass Spectrom 40:389-99 (2005). Read more (PubMed: 15674857) »
See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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