Key features and details
- Rabbit polyclonal to Anthrax EF/Adenylyl cyclase
- Suitable for: ELISA
- Reacts with: Species independent
- Isotype: IgG
Product nameAnti-Anthrax EF/Adenylyl cyclase antibody
DescriptionRabbit polyclonal to Anthrax EF/Adenylyl cyclase
Tested applicationsSuitable for: ELISAmore details
Species reactivityReacts with: Species independent
Synthetic peptide corresponding to Anthrax EF/Adenylyl cyclase (C terminal).
This product was previously labelled as Anthrax EF
Storage instructionsShipped at 4°C. Store at +4°C.
Storage bufferPreservative: 0.02% Sodium azide
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab21267 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|ELISA||Use a concentration of 1 µg/ml. Note: at this concentration ab21267 will detect 10 ng of free peptide.|
RelevanceAnthrax infection is initiated by inhalation, ingestion or cutaneous contact with Bacillus anthracis endospores. B. anthracis produces three polypeptides that comprise the anthrax toxin: protective antigen (PA), lethal factor (LF) and edema factor (EF). PA binds to two related proteins on the cell surface; these are termed tumor epithelial marker 8 (TEM8)/anthrax toxin receptor (ATR) and capillary morphogenesis protein 2 (CMG2), although it is still unclear which is physiologically relevant. Following PA binding to its receptor, PA is cleaved into two fragments by a furin like protease. The bound fragment binds both LF and EF; the resulting complex is then endocytosed which allows the translocation of LF and EF into the cytoplasm. EF is a calmodulin and Ca++ dependent adenylate cyclase responsible for the edema seen in the disease. It is thought to benefit the B. anthracis bacteria by inhibiting cells of the host immune system.
- Adenylyl cyclase antibody
- Bacillus anthracis EF antibody
- Cya antibody
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab21267 has been referenced in 1 publication.
- He L et al. Deficiency of FAM3D (Family With Sequence Similarity 3, Member D), A Novel Chemokine, Attenuates Neutrophil Recruitment and Ameliorates Abdominal Aortic Aneurysm Development. Arterioscler Thromb Vasc Biol 38:1616-1631 (2018). PubMed: 29853563