Overview

  • Product name
    Antimycin A, Antibiotic
  • Description
    Antibiotic; induces apoptosis
  • Biological description
    Antibiotic. Induces apoptosis and inhibits mitochondrial electron transport specifically between cytochromes b and c1.
  • Purity
    > 95%

Properties

  • Chemical name
    [(2R,3S,6S,7R,8R)-3-[(3-Formamido-2-hydroxybenzoyl)amino]-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl] 3-methylbutanoate (for Antimycin A1: R = C6H13)
  • Molecular weight
    548.63
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C28H40N2O9 (for Antimycin A1, R = C6H13)
  • CAS Number
    1397-94-0
  • PubChem identifier
    14957
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in ethanol to 100 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    CCCCCC[C@@H]1[C@H]([C@@H](OC(=O)[C@H]([C@H](OC1=O)C)NC(=O)C2=C(C(=CC=C2)NC=O)O)C)OC(=O)CC(C)C
  • Source

    Streptomyces sp.

  • Research areas

References

This product has been referenced in:
  • Choi EM Magnolol protects osteoblastic MC3T3-E1 cells against antimycin A-induced cytotoxicity through activation of mitochondrial function. Inflammation 35:1204-12 (2012). Read more (PubMed: 22281543) »
  • Choi EM Luteolin protects osteoblastic MC3T3-E1 cells from antimycin A-induced cytotoxicity through the improved mitochondrial function and activation of PI3K/Akt/CREB. Toxicol In Vitro 25:1671-9 (2011). Read more (PubMed: 21782929) »
  • Choi EM Honokiol protects osteoblastic MC3T3-E1 cells against antimycin A-induced cytotoxicity. Inflamm Res 60:1005-12 (2011). Read more (PubMed: 21800176) »
See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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