Overview

  • Product name

    Anti-Antithrombin III/ATIII antibody
    See all Antithrombin III/ATIII primary antibodies
  • Description

    Chicken polyclonal to Antithrombin III/ATIII
  • Host species

    Chicken
  • Specificity

    The antibody has been tested against purified human plasma Antithrombin III/ATIII protein. It has yet to be tested against whole plasma samples.

  • Tested applications

    Suitable for: WB, ELISAmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Full length protein corresponding to Human Antithrombin III/ATIII.

  • Positive control

    • Purified Human plasma Antithrombin III/ATIII protein.
  • General notes

    Previously labelled as Antithrombin III.

Properties

Applications

Our Abpromise guarantee covers the use of ab19105 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500. Detects a band of approximately 49 kDa (predicted molecular weight: 53 kDa).
ELISA Use at an assay dependent dilution.

Target

  • Function

    Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin.
  • Tissue specificity

    Found in plasma.
  • Involvement in disease

    Defects in SERPINC1 are the cause of antithrombin III deficiency (AT3D) [MIM:613118]. AT3D is an important risk factor for hereditary thrombophilia, a hemostatic disorder characterized by a tendency to recurrent thrombosis. AT3D is classified into 4 types. Type I: characterized by a 50% decrease in antigenic and functional levels. Type II: has defects affecting the thrombin-binding domain. Type III: alteration of the heparin-binding domain. Plasma AT-III antigen levels are normal in type II and III. Type IV: consists of miscellaneous group of unclassifiable mutations.
  • Sequence similarities

    Belongs to the serpin family.
  • Post-translational
    modifications

    Phosphorylation sites are present in the extracelllular medium.
  • Cellular localization

    Secreted > extracellular space.
  • Information by UniProt
  • Database links

  • Alternative names

    • ANT3_HUMAN antibody
    • Antithrombin antibody
    • Antithrombin III antibody
    • Antithrombin-III antibody
    • AntithrombinIII antibody
    • AT 3 antibody
    • AT III antibody
    • AT3 antibody
    • AT3D antibody
    • ATIII antibody
    • Heparin cofactor I antibody
    • MGC22579 antibody
    • Serine (or cysteine) proteinase inhibitor clade C (antithrombin) member 1 antibody
    • Serine cysteine proteinase inhibitor clade C member 1 antibody
    • Serine proteinase inhibitor clade C member 1 antibody
    • Serpin C1 antibody
    • Serpin family C member 1 antibody
    • Serpin peptidase inhibitor clade C (antithrombin) member 1 antibody
    • SERPINC1 antibody
    • THPH7 antibody
    see all

Images

  • ab19105 at 1/2000 staining human plasma Antithrombin III/ATIII protein by Western blot. ab19105 at 1/2000 staining human plasma Antithrombin III/ATIII protein by Western blot.

References

This product has been referenced in:

  • Papareddy P  et al. Antimicrobial effects of helix D-derived peptides of human antithrombin III. J Biol Chem 289:29790-800 (2014). Read more (PubMed: 25202017) »
See 1 Publication for this product

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